Paramyxovirus Flashcards
What is the leading viral cause of serious lower respiratory tract infections in infants?
RSV….second leading cause if hMPV
What is the Microbe biology and genome structure of the Paramyxoviruses
Enveloped, non-segmented, Negative sense
Parts of the replication cycle that are differnt from coronavirus
first event following virus entry is transcription of viral mRNAs from the neagative strand genome.
Is Virus entry pH dependent of independent
independent
Tropisms of these viruses restricted to where?
cells of the upper and lower respiratory tract
What is the F protein
Fusion protein, found on all three viruses, responsible for virus entry and fusion to adjacent cells which results in a syncytia.
hPIV and hMPV bind to what part of the mucou membrane layer lining the respiratory tract
Sialic acid. Binds this via HN protein
The two major envelope glycoproteins for RSV are
F - fusion and G- Binds GAGs on the airway epithelium
Two major envelope glycoproteins for hMPV and hPIV
F and HN
Cells infected with these viruses fuse together in syncytia.
true
Primary tissues targeted in teh lungs are
airway epithelial cells, RSV has been shown to also infect lung dendritic cells
Initial infection occures where
URT…then infection spreads down via cell to cell transfer or by riding on the dendritic cells.
chief pathologic features
airway inflammation, necrosis, sloughing of respiratory epithelium, edema, excessive mucous, interstitial infiltration of the lung.
hPIV causes swelling in the vocal cords, larynx, trachea,and bronchi. Leads to stridor
true
HPIV3 is second only to RSV as a cause of pneumonia and bronchiolitis
HPIV 1,2 and 3 are generally associated with croup syndrome where infection of the larynx and upper trachea are involved
