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Pulmonology > Drugs for Restrictive Lung Disease and Pulm Artery HTN > Flashcards

Drugs for Restrictive Lung Disease and Pulm Artery HTN Flashcards

1
Q

Silicosis increases your risk for

A

TB

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2
Q

Coal Workers Pneumocosis increases risk for?

A

Right sided heart failure

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3
Q

Asbestosis increases your risk for carcinoma and mesotheliom

A

true

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4
Q

Berryliosis increases your risk for?

A

multi-organ granuloma formation

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5
Q

What drugs have been shown to precipitate ARDS

A

Aspirin, Cocaine, Opioids, Phenothiazines, tricyclic anti-depressants

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6
Q

Alcohol abuse and ARDS

A

Alcohol abuse increases the risk of ARDS due to other causes but does not cause ARDS

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7
Q

NRDS

A

Neonatal Respiratory Distress Syndrome….Most common cause of respiratory failure in newborns. Surfactant deficiency–> increased surface tension, V/Q mismatch and shunting.

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8
Q

How do you treat NRDS

A

Give corticosteroids to women at risk of delivering early. This enhances fetal lung maturation

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9
Q

For babies born at less than 30 weeks, exogenous surfactant is administered.

A

True…give poractant alfa, calfactant, Beractant

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10
Q

Hall mark of Sarcoidosis

A

Non-caseating granulomas

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11
Q

Treatment of sarcoidosis

A

gluccocorticoids (anti-inflammatory), methotrexate (immunosuppression)

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12
Q

Gluccocorticoids

A

MOST POTENT ANTI-INFLAMMATORY AGENTS, act by BINDING GLUCOCORTICOID RECEPTOR and modulating transcriptional regulation in the nucleus. Prevent the production of inflammatory cytokines IL-1 and TNF Alpha and promoting IL-10 production (anti-inflammatory)

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13
Q

Is pulmonary fibrosis an interstitial lung disease?

A

No way. It doesn’t react to steroid treatment. Some clinicians use steroids to decide whether it is pulm fibrosis or not.

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14
Q

What is goodpastures syndrome

A

Type II Hypersensitivity reaction against the alpha III chain of Type IV Collagen

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15
Q

Wegners

A

ANCA positive autoimmune vasculititis of small medium vessels

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16
Q

What are prostanoids

A

drugs that induce pulmonary artery vasodilation, retard smooth muscle growth, and disrupt platelet aggregation.

17
Q

PAH is a devastating disease

A

Drug costs over 35,000 annually because there is not an oral form. lloprost is the only form thats not IV, Epoprostenol and treprostinil are both IV drugs only. Drugs have a limited shelf life.

18
Q

Four categories of PAH drugs

A

Prostanoids, Endothelin 1 Receptor Antagonists, Phosphodiesterase Type 5 Inhibitors, CCBs

19
Q

What are Endothelin 1 Receptor antagonists

A

block smooth muscle proliferation and pulmonary artery vasoconstriction produced by endothelin when it binds to receptors.

20
Q

What are phsophodiesterase Type 5 inhibitors

A

perpetuate cGMP production leading to vasodilation and reduced proliferation

21
Q

What is the Precaution when prescribing phosphodiesterase type 5 inhibitors

A

DO NOT GIVE TO PATIENTS TAKING ORGANIC NITRATES

22
Q

How do calcium channel blockers work

A

Prevent access to of calcium into cells during membrane depolarization and block smooth muscle contraction

23
Q

How does methotrexate work

A

Increases Adenosine-mediated immunosuppresion

24
Q

What are the prostanoids we need to know

A

EpoPROSTenol and Lloprost and Treprostinil

25
Q

What are the Endothelin type 1 antagonists we need to know

A

Bosentan and Ambrisentan

26
Q

What is the black box warning for Lloprost?

A

Hemoptysis

27
Q

What is the calcium channel blocker we need to know

A

Diltiazem ,Amlodipine

28
Q

What is Rituximab?

A

monoclonalantibody against CD20 on B cells, it is anti-inflammatory

29
Q

What do you treat with Rituximab

A

Wegners, both sound german

30
Q

How does Azothioprine work>

A

Inhibits DNA and RNA synthesis and fcilitates apoptosis of T cells thus promoting immunosuppression.

31
Q

What do you treat with Azathioprine

A

Wegners

32
Q

Big SE for calc channel blockers>

A

hypotension

Pulmonology (41 decks)

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