Coronavirus

Question 1

What is the morphology of the corona virus under the electron microscope

Answer 1

crown like

Question 2

Cause what types of infections

Answer 2

respiratory and enteric

Question 3

Most coronaviruses cause

Answer 3

common cold

Question 4

Describe the virus and its genome

Answer 4

Enveloped, Non-segmented, Positive Sense

Question 5

What virus has the larges viral genome int eh world

Answer 5

Coronavirus

Question 6

Of the 3 groups of coronaviruses, which one’s can infect humans

Answer 6

Groups 1 and 2

Question 7

Spike protein does what

Answer 7

Binds to host cell surface receptors, fusion of viral membrane to cellular plasma membrane

Question 8

E-protein (Envelope protein)

Answer 8

viral morphogenesis, assembly, budding, and ion channel activity involved in viral replication

Question 9

M protein

Answer 9

Transmembrane protein important for virus budding and envelope formation

Question 10

Replication strategy

Answer 10

Following entry and uncoating, genomic RNA is translated to generate replicase proteins, these proteins use the genome as a template to generate full length antigenomic RNAs which again serve as templates for addittional genomes.
Minus strand sub-genomic RNAs are synthesized using the genomic RNA as template in a discontinuous fashion producing overlapping RNAs with 5’ and 3’ ends. These RNAs serve as templates for production of Viral mRNA which when translated leads to non-replicase proteins. The virla RNA dependent RNA polymerase has a high error rate. This along with virla recombination leads to the generation of new genomes which may be selectively advantageous

Question 11

What diseases can Coronaviruses cause

Answer 11

cold, croup, exacerbations of asthma and bronchitis, Pneumonia in infants, children and immunocompromised pts. SARS

Question 12

What is SARS

Answer 12

lower resp tract infection, most progress to pneumonia. Infection of type II pneumocytes leads to diffuse alveolar damage. Can cause systemic infection of the liver, GI tract, Kidney, brain

Question 13

SARS symptoms

Answer 13

flu-like, then dry cough shortness of breath, hypoxia, GI distress, lymphopenia

Question 14

Transmission

Answer 14

airborne or contact with contaminated surfaces

Question 15

When to consider SARS

Answer 15

in patients who require hospitilization for radiographically confirmed pneumonia and have history that raises suspicion….travel to asia, works in lab with SARS, part of a cluster of atypical cases

Question 16

Treatment for RSV

Answer 16

Ribavirin, palvizumab