Respiratory High Yield

Question 1

Mechanism of action of short-acting beta agonists

Answer 1

Increase cAMP–>smooth muscle relaxation

Question 2

Black box warning for LABA

Answer 2

Don’t use as monotherapy–need inhaled corticosteroid for protection

Question 3

Caution for anti-cholinergics

Answer 3

Glaucoma, BPH, myasthenia gravis

Question 4

Side effects from corticosteroids

Answer 4

Pneumonia, oral thrush, voice change

Question 5

First-line controller of asthma therapy

Answer 5

Inhaled corticosteroids

Question 6

Beta agonist suffix

Answer 6

erol

Question 7

Anticholinergic suffix

Answer 7

ium

Question 8

Corticosteroid suffix

Answer 8

sone

Question 9

First-line controller of COPD

Answer 9

LABA or LAMA

Question 10

Which drug necessitates blood level monitoring

Answer 10

Theophylline

Question 11

Mechanism of action of nintedanib

Answer 11

Kinase inhibitor that blocks multiple pathways involved in fibrosis formation

Question 12

Only group for which PH treatment is indicated

Answer 12

Group 1–pulmonary arterial hypertension

Question 13

Endothelin receptor antagonist side effects

Answer 13

Peripheral edema
Liver function abnormalities
Anemia

Question 14

Drugs for idiopathic pulmonary fibrosis

Answer 14

Pirfenidone and nintedanib

high incidence of GI side effects

Question 15

What are the side effects for PDE4 inhibitors

Answer 15

GI upset, diarrhea, weight loss

Question 16

What is the unique drug for COPD and how does it work?

Answer 16

PDE4 inhibitors–>anti-inflammatory effects but also GI issues