Antifungals Flashcards
1
Q
Which drugs are fungicidal?
A
Polyenes
Allylamines
Echinocandins
2
Q
Which drugs are fungistatic?
A
Azoles
Flucytosine
Griseofulvin
3
Q
Polyenes
A
Amphotericin B
Nystatin
4
Q
Polyene MOA
A
Bind ergosterol–>membrane pores
5
Q
Why would you use amphotericin B?
A
Intrathecally for meningitis
6
Q
Azole MOA
A
Inhibit 14asterol demethylase (a sterol is created, but not ergosterol)
7
Q
Allylamine
A
Terbinafine
8
Q
Polyene dose-limiting toxicity
A
Nephrotoxicity
9
Q
Allylamine MOA
A
Inhibit squalene epoxidase
10
Q
Allylamine use
A
Treatment of dermatophytosis
11
Q
Echinocandins
A
-fungins
12
Q
Echinocandins MOA
A
Inhibit B-1,3 glucan synthesis
13
Q
Echinocandins interactions
A
Cyclosporine increases caspofungin levels
14
Q
Flucytosine MOA
A
Inhibits fungal DNA/RNA/protein synthesis
15
Q
Does flucytosine penetrate CSF?
A
Yes
