Antiviral highlighted

Question 1

What is the structure of most anti-herpetics?

Answer 1

Nucleoside/nucleotide analogs

Question 2

What activates acyclovir?

Answer 2

Monophosphorylation by viral TK

Question 3

What is the difference between acyclovir and penciclovir?

Answer 3

Penciclovir is less potent but has a longer half-life (good for long-term treatment of herpes)

Question 4

What activates ganciclovir?

Answer 4

CMV phosphotransferase

Question 5

Side effects of ganciclovir

Answer 5

Neutropenia
Thrombocytopenia
Leukopenia

Question 6

What must be administered with cidofovir to limit nephrotoxicity?

Answer 6

Probenecid

Question 7

Does cidofovir cross BBB?

Answer 7

No

Question 8

Foscarnet side effects

Answer 8

Nephrotoxicity

Hypocalcemia

Question 9

Does foscarnet need TK activation?

Answer 9

No

Question 10

What is the leading infectious cause of blindness?

Answer 10

Ocular HSV keratitis

Question 11

Against which disease do amantidine and rimantidine work?

Answer 11

Influenza A

Question 12

What is oseltamivir and zanamivir’s target?

Answer 12

Neuraminidase

Question 13

Standard of care for HCV

Answer 13

PEG IFN a and ribavirin

Question 14

Predominant IFN in US

Answer 14

a

Question 15

Dose limiting toxicities of ribavirin

Answer 15

Hemolytic anemia, marrow suppression, teratogen

Question 16

What drugs does maraviroc interact with?

Answer 16

CYP metabolites

Question 17

Who can take enfurtivide?

Answer 17

Adults with HIV replication despite treatment

Question 18

What do NRTIs inhibit?

Answer 18

HIV RT (selectively over cellular polymerase)

Question 19

What aspect of NRTIs causes a negative effect?

Answer 19

Inhibition of mitochondrial polymerase

Question 20

Do NRTIs have a long or short half life

Answer 20

LONG (relative to parent compound)

Question 21

Which NRTIs cannot be combined

Answer 21

Stavudine and zidovudine

Question 22

What drugs do NNRTIs interact with?

Answer 22

CYP metabolites

Question 23

Use for acyclovir

Answer 23

HSV, VZV, Shingles

Question 24

Use for penciclovir

Answer 24

Shingles (less potent, longer half life)

Question 25

Use for ganciclovir

Answer 25

CMV

Question 26

Use for cidofovir/foscarnet

Answer 26

Resistance