CYPs of interest

Question 1

CYP1A

Answer 1

Metabolize polycyclic hydrocarbons

AhR

Question 2

CYP1A1

Answer 2

Inducible

Extrahepatic

Question 3

CYP1A2

Answer 3

Inducible
Constitutively expressed only in liver

Induced by broccoli and cauliflower, cigarette smoke, caffeine

Question 4

CYP1B1

Answer 4

Ah receptor inducible

Metabolizes PAHs, steroids, retinoic acid, arachidonic acid

Question 5

CYP1B1 deficiency

Answer 5

Primary congenital glaucoma

Question 6

CYP2A6

Answer 6

Expressed in liver
Metabolizes nicotine
Polymorphisms associated with LOWER risk of nicotine addiction

Question 7

CYP2A13

Answer 7

Expressed in respiratory tract

Metabolizes nitrosamine NNK

Question 8

CYP2B6

Answer 8

Inducible by constitutive active receptor

Metabolizes MDMA, flame retardants

Question 9

CYP2C

Answer 9

Metabolize 30% of commonly used drugs

All forms polymorphic

Question 10

CYP2E1

Answer 10

Inducible, constitutively expressed
Forms reactive intermediates (nitrosamine carcinogens, acetaminophen)

Induced by ethanol, so related to “tylenol for a hangover” toxicity (NAPQI)

Question 11

CYP3A4/5

Answer 11

Major ones in humans
Inducible by numerous drugs and pregnane X receptor
5 affects behavior of 4
Inhibited by grapefruit juice

Question 12

CYP2D6

Answer 12

Opioids

SSRI&Tamoxifen interaction