Abs from Lecture I

Question 1

Quinolone administration

Answer 1

Oral

Question 2

Quinolone absorption

Answer 2

Interference from dairy products

Question 3

Quinolone distribution

Answer 3

Widespread (including cells, some in breastmilk)

Question 4

Quinolone excretion

Answer 4

Kidneys

Question 5

Quinolone toxicity

Answer 5

GI
Arthropathy in children
Tendonopathy in adults
(Fluoroquinolones hurt attachments to your bones)

Question 6

Penicillin administration

Answer 6

Oral, IM, IV

Question 7

Penicillin distribution

Answer 7

Wide, bound to serum albumin, EXCEPT CNS, prostatic fluid, eye

Question 8

Penicillin excretion

Answer 8

Kidneys (and breastmilk)

Question 9

Penicillin toxicity/contraindications

Answer 9

All 4 types of hypersensitivity
Issues with renal failure
Some CNS issues

Question 10

Cephalosporin administration

Answer 10

Parenteral

Question 11

Cephalosporin penetration

Answer 11

INTO CNS (hence good for meningitis)

Question 12

Cephalosporin contraindication

Answer 12

Penicillin cross-reactivity

Question 13

Carbapenem administration

Answer 13

IV

Question 14

Imipenem administration

Answer 14

With cilastatin to slow renal excretion

Question 15

Carbapenem excretion

Answer 15

Renal

Question 16

Carbapenem toxicity

Answer 16

GI

Hypersensitivity (but no cross-reactivity with penicillin)