GI Pharm Flashcards

1
Q

Benign ulcers

A

Normal acid production, weak mucosal barrier

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2
Q

Malignant ulcers

A

Increased acid production, normal mucosal barrier

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3
Q

H2 receptor blockers

A

-tidine

Cimetidine, famotidine, ranitidine, nizatidine

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4
Q

PPIs

A

-prazoles

Omeprazole, esomeprazole, rabeprazole, lansoprazole, pantoprazole

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5
Q

Prostaglandin

A

Misoprostol

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6
Q

Prostaglandin MOA

A

Maintains mucosal barrier (via COX pathway)

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7
Q

Prostaglandin use

A

PUD and GERD caused by NSAID injury

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8
Q

Anticholinergic

A

Pirenzepine

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9
Q

Mucosal protective agents

A

Sucralfate and chelated bismuth

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10
Q

Triple therapy

A

PPI, moderate antibiotic, strong antibiotic

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11
Q

Quadruple therapy

A

PPI, moderate antibiotic, strong antibiotic, chelated bismuth

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12
Q

Treatment for mild Crohn’s

A

-salazines

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13
Q

Treatment for moderate Crohn’s

A

Prednisolone

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14
Q

Treatment for active and chronic Crohn’s

A

Thiopurines, MTX

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15
Q

Laxative MOA

A

Increase diameter of intestinal lumen

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16
Q

Laxative classes

A

Bulking
Osmotic
Stool softener
Stimulant

17
Q

Bulk laxatives

A

Non-digestible fiber

18
Q

Osmotic laxatives

A

Non-digestible sugars/alcohols
Salts
PEG

19
Q

Stool softeners

A

Docusate sodium

20
Q

Stimulant

A

Castor oil
Senna
Bisacodyl
Lubiprostone

21
Q

Anti-diarrheal MOA

A

Stimulate opioid receptors–>reduce motility

22
Q

Anti-diarrheals

A

Diphenoxylate (+atropine)

Loperamide (doesn’t cross BBB)

23
Q

Anti-flatulent

A

Simethicone (detergent)

24
Q

Anti-emetic

A

M1 blocker
H1/D2 blocker
5-HT3 blocker

25
Q

M1 blocker

A

Scopolamine

26
Q

H1/D2 blockers

A

Phenothiazines

27
Q

5-HT3 blockers

A

Ondansetron, granisetron