Alkylating agents Flashcards

1
Q

MOA

A

Cause DNA cross-linking–>prevent replication

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2
Q

Intrinsic resistance

A

p53 mutation

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3
Q

Nitrogen mustards

A

Cyclophosphamide

Melphalan

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4
Q

Nitrosureas

A

Carmustine, lomustine

Streptozotocin/Streptozocin

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5
Q

Hydrazines

A

Procarbazine

Dacarbazine

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6
Q

Platinums

A

Cisplatin

Carboplatin

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