Abs from Lecture II

Question 1

Aminoglycoside administration

Answer 1

IV

Question 2

Aminoglycoside absorption

Answer 2

Poor

but DOES accumulate in the inner ear

Question 3

Aminoglycoside toxicity

Answer 3

Neuromuscular blockade
Nephrotoxicity
Ototoxicity
Teratogenic

Question 4

Aminoglycoside excretion

Answer 4

Kidneys

Question 5

Tetracycline administration

Answer 5

Oral or PO

Question 6

Tetracycline administration

Answer 6

Hindered by divalent cations AKA DAIRY

Question 7

Tetracycline distribution

Answer 7

Incompletely absorbed from stomach

Question 8

Mino/doxycycline distribution

Answer 8

Completely absorbed from stomach

Question 9

Tetracycline excretion

Answer 9

Renal

Question 10

Mino/doxycycline excretion

Answer 10

Liver

Question 11

Tetracycline toxicity

Answer 11

GI, hepatic, renal
FANCONI Syndrome
Photosensitivity
Deposits in tooth dentin and enamel

Question 12

Macrolide administration

Answer 12

Oral

Question 13

Macrolide absorption

Answer 13

Upper SI

Question 14

Macrolide distribution

Answer 14

ALL fluids except CSF/brain

Question 15

Macrolide excretion

Answer 15

Kidney/liver

Question 16

Which macrolide can be given with food?

Answer 16

Clarithromycin

Question 17

Macrolide toxicity

Answer 17

Epigastric distress with large doses
Cholestatic hepatitis
Prolonged QT interval

Question 18

Chloramphenicol administration

Answer 18

Oral/IV

Question 19

Chloramphenicol distribution

Answer 19

ALL fluids

Question 20

Chloramphenicol excretion

Answer 20

Kidneys

Question 21

Chloramphenicol toxicity

Answer 21

Gray baby syndrome

Question 22

Clindamycin administration

Answer 22

All

Question 23

Clindamycin distribution

Answer 23

EVERYWHERE besides CSF

Question 24

Clindamycin excretion

Answer 24

Liver and kidneys

Question 25

Clindamycin toxicity

Answer 25

Diarrhea, pseudomembranous colitis–>toxic megacolon, skin rash, anaphylaxis