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Pharmacology > Abs from Lecture II > Flashcards

Abs from Lecture II Flashcards

1
Q

Aminoglycoside administration

A

IV

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2
Q

Aminoglycoside absorption

A

Poor

but DOES accumulate in the inner ear

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3
Q

Aminoglycoside toxicity

A

Neuromuscular blockade
Nephrotoxicity
Ototoxicity
Teratogenic

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4
Q

Aminoglycoside excretion

A

Kidneys

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5
Q

Tetracycline administration

A

Oral or PO

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6
Q

Tetracycline administration

A

Hindered by divalent cations AKA DAIRY

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7
Q

Tetracycline distribution

A

Incompletely absorbed from stomach

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8
Q

Mino/doxycycline distribution

A

Completely absorbed from stomach

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9
Q

Tetracycline excretion

A

Renal

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10
Q

Mino/doxycycline excretion

A

Liver

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11
Q

Tetracycline toxicity

A

GI, hepatic, renal
FANCONI Syndrome
Photosensitivity
Deposits in tooth dentin and enamel

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12
Q

Macrolide administration

A

Oral

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13
Q

Macrolide absorption

A

Upper SI

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14
Q

Macrolide distribution

A

ALL fluids except CSF/brain

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15
Q

Macrolide excretion

A

Kidney/liver

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16
Q

Which macrolide can be given with food?

A

Clarithromycin

17
Q

Macrolide toxicity

A

Epigastric distress with large doses
Cholestatic hepatitis
Prolonged QT interval

18
Q

Chloramphenicol administration

A

Oral/IV

19
Q

Chloramphenicol distribution

A

ALL fluids

20
Q

Chloramphenicol excretion

A

Kidneys

21
Q

Chloramphenicol toxicity

A

Gray baby syndrome

22
Q

Clindamycin administration

A

All

23
Q

Clindamycin distribution

A

EVERYWHERE besides CSF

24
Q

Clindamycin excretion

A

Liver and kidneys

25
Q

Clindamycin toxicity

A

Diarrhea, pseudomembranous colitis–>toxic megacolon, skin rash, anaphylaxis

Pharmacology (52 decks)

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