resp pharm

Question 1

tox of H1 blockers

Answer 1

sedation, antimuscarinic, anti-a-adregeneric

Question 2

short acting B2 agonists for asthma

Answer 2

albuterol

Question 3

longa cting b2 agonists for asthma

Answer 3

salmeterol, formoterol

Question 4

SE of LABAs

Answer 4

tremor and arrthymia

Question 5

theophylline MOA

Answer 5

causes bronchodilation by inhibiting phosphodiesterase - inhibiting cAMP hydrolysis

Question 6

tox of theophylline

Answer 6

very small theraputic index, can cause cardio/neurotox - metabolzed by P450

Question 7

MOA of ipratropium

Answer 7

competitive block of muscarinic receptors, preventing brochorestriction

Question 8

MOA of steroids in asthma

Answer 8

inactivates NF-kB–> decreased TNF-a, among other inflammatory agents. 1st line therapy for chronic asthma

Question 9

steroids used for asthma

Answer 9

beclomethasone and fluticasone

Question 10

bosentan use

Answer 10

pulmonary arterial hypertension

Question 11

MOA of bosentan

Answer 11

competitively antagonizes endothelian-1 receptors, decreasing vascular resistance

Question 12

dextramethorphan use

Answer 12

antitussive

Question 13

dextramethorphan MOA

Answer 13

antagonizes NMDA glutamate receptors

Question 14

pseudoehpedrine MOA

Answer 14

symathetic a-agonist

Question 15

use of methacholine

Answer 15

asthma challenge testing

Question 16

MOA if methacholine

Answer 16

muscarinic receptor testing