heme pharm Flashcards
MOA of Heperin
cofactor for activation of antithrombin. reduces thrombin and factor xa
use of heparin
immediate antocoag for PE, acute coronary syndrome, MI, DVT
anticoag safe in pregnancy
heparin
antidote for heparin OD
protamine sulfate
type of heparin not easily reversable
low molecular weight
reaction to heparin that can cause thombosis and thrombocytopenia
HIT - development of IgG antibodies against heparin, forms antibody complex that actiavtes platelets leading to thombosis
used as alternative to heparin in HIT
lepirudin, bivalirudin
MOA of warfarin
interferes with synth and activation of vit K dependant clotting factors
clinical effect of warfarin
effects extrinsic pathway, increasing PT
use of warfarin
chronic anticoag (post STEMI, venous thromboembolism prophalaxis, prevention of stroke in Afib)
ongoing tests for warfarin use
PT/INR values
tox of warfarin
bleeding, birth defects, skin/tissue necrosis, drug-drug interaction
drug that interferes with damn near everything
warfarin
reversal of warfarin
vit K (fresh frozen plasma if severe)
site of action of heparin/warfarin
blood/liver