Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 1 - Pharm > neuro - pharm > Flashcards

neuro - pharm Flashcards

1
Q

drugs to use in glaucoma

A 
epi (NOT IN CLOSED ANGLE)
Brimonidine
timolol, betaxolol, carteolol
acetazolamide
pilocarpine, carbachol
physostigmine, echothiphate
latanoprost
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

SE of brimonnidine

A

blurry vision, ocular hyperemia, forgein body sensation, ocular allergic reaction, ocular pruitus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MOA of opioid

A

opens K channels, close Ca channels to decrease synaptic tranmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

opiod that causes less respiratory depression

A

butoprphanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

tox of butorphanol

A

can cause opioid wd sx if taken with full opiod agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

very weak opioid agonist that inhibits Seotinin and NE reuptake

A

tramadol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

tox of tramadol

A

decreases seizure threshold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

1st line for tonic-clonic sezioures

A

phenytoin, carbamazepine, valporic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

1st line for complex and simple seziures

A

carbamazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

1st line for absence seuires

A

ethosuximide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

1st line for status epilepticus

A

phenytoin for prevention, benzo for acute (diazepam/lorezapam)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA of phenytoin and carbemazepine

A

increases Na channel activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

1st line for trigeminal neuralgia

A

carbamazapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

non seizure uses for gabapentin

A

used for peripheral neuropathy, neuralgia, migrane prophylaxis, bipolar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MOA of gabapentin

A

inhibits voltage gated Ca channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

valproic acid MOA

A

Na channel inactivation, increases GABA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ethosuximide MOA

A

blocks thalmic t-type Ca channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

tx for eclampsia seizures

A

benzo and MgSO4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Tox of carbamazepine

A

diplopia, ataxia, agranulocytosis, aplastic anemia, liver tox, SIADH, stevens-johnson

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

tox of ethosuximide

A

GI distress, fatigue, headache, stevens-johnson

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

tox of phenytoin

A

gingval hyperplasia, hirsuitism, SLE-like syndrome,sedation, nystagmus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

tox of valpoic acid

A

GI distress, rare but fatal heptotox, tremor and weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

seziure drug NOT to be used in pregnancy

A

valproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

gabapentin tox

A

sedation, ataxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

MOA of barbos

A

facilitate GABA action by increasing duration of Cl-channel opening

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

contraindications of barbos

A

porphyria, EtOH use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

MOA of benzos

A

faciliate GABA action by increasing frequency of Cl- channel opening

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

use of benzos,

A

anxiety, spasticity, status elipticus, EtOH detox,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

treat OD of benzo with

A

flumazenil

30
Q

non benzo hypnotics

A

zolpidem, zalaplon, eszoplicone

31
Q

MOA of non benzo hypnotics

A

act via BZ1 subtype of GABA receptor

32
Q

property of potent anesthetics

A

lipid solulability, 1/MAC

33
Q

MAC def.

A

minimum alveolar concentration that 50% of population is anethestized

34
Q

effects of inhaled anesthetics

A

myocardial/resp depression, n/v, higher cerebral blood flow

35
Q

tox of halothane

A

hepatotix

36
Q

tox of methoxyflurane

A

nephrotox

37
Q

tox of enflurane

A

proconvulsant

38
Q

tox of all inhaled anethetics

A

malignant hyperthermia (not NO)

39
Q

high potency, rapid effect anesthetic with short duration

A

thiopental (Barbo)

40
Q

use of thiopental

A

induction and short procedures

41
Q

use of midzolam

A

endoscopy

42
Q

tox of midzolam

A

severe resp depression, low BP, and amnesia

43
Q

use of propofol

A

sedation in ICU, rapid inductin, short procedures (less nausea than thipental)

44
Q

Local anethetic esters

A

procaine, cocaine, tetracaine (one I)

45
Q

local anesthetic amides

A

anything with 2 Is

46
Q

MOA of local anesthetics

A

Blocks Na channels FROM THE INSIDE of the channel. preferentially bind actiaved Na channels.

47
Q

given with local anethetics to increase local action

A

epi

48
Q

problem with giving local anesthetics to infected tissue

A

infected tissue is acidic. The drugs are alkaline, so can’t penetrate the membrane and you have to give more

49
Q

nerves that are blockaded first

A

small-diameter and myelnated fibers

(order of loss: Pain, temp, touch, pressure

50
Q

tox of local anesthetics

A

CNS excititaion, CV tox, nypertension, hypotension

51
Q

Tox of bupivicane

A

Cardiotox

52
Q

depolarizing neuromusclular blocker

A

succinocholine

53
Q

MOA of succinylcholine

A

strong ACh receptor agonist - produces sustained depolarization and prevents muscular contraction

54
Q

antidote for phase II succ

A

neostigmine

55
Q

nondepolarizing NM blockers

A

tubocurarine, -curiums, s

56
Q

nondepolarizing NM blockers MOA

A

competitive ACh blockers

57
Q

reversal of nondepolarizing NM blockers

A

neostigmine edrophonium and cholinesterase inhibitors

58
Q

use of dantrolene

A

reverse malignant hyperthermia and neuroleptic malignint syndrome

59
Q

parkinson dopamine agonists

A

bromocriptine, pramipexole

60
Q

parkinson dopamine increasers

A

amantadine, L-dopa/carbidopa

61
Q

parkinson drugs to decrease breakdown of dopamine

A

selegilinem entcaponem tolacapone

62
Q

parkinson drugs to curb excess cholingernic activity

A

benztropine

63
Q

tox of amantadine

A

ataxia

64
Q

tox of l-dopa/carbipoda

A

arythmias, long term dyskinesias

65
Q

tox of selegiline

A

may enhance L-dopa adverse effects

66
Q

MOA of selegiline

A

MAO-B inhibitor (slows metabolism of dopamine)

67
Q

MOA of memantine

A

NMDA receptor antagonist, prevents Ca++ exitotox

68
Q

SE of memantidine

A

dizziness, confusion, hallucinations

69
Q

MOA of donezepil, galantamine, rivastigmine

A

AChE inibitors

70
Q

tox of AChE inhibitors for alzheimers

A

Nausea, dizziness, insomnia

71
Q

tx for huntington’s

A

tetrabenzine/reserpine (inhibit VMAT release of dopamine)

haldol (dopamine receptor antagonist)

72
Q

tox of sumatriptan

A

coronary vasospasm

Step 1 - Pharm (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions