general drug reactions Flashcards

1
Q

can cause coronary vasospasm

A

cocaine, sumatriptan, ergot alkaloids

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2
Q

skin flushing

A

vancomycin, adenosine, niacin, CCBs

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3
Q

dilated cardiomypathy

A

doxorubicin, daunoribicin

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4
Q

torsades de pointes

A

sotalol (class III antiarrythmic) and quinadine (class IA antiarythmic)

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5
Q

agranulocytosis

A

clozapine, carbamazepine, colchine, propythiouracil, methimazole, dapsone

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6
Q

aplastic anemia,

A

chloramphenicol, benzene, NSAIDS, proplythiouracil, methimazole

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7
Q

direct coombs (+) hemolytic anemia,

A

methyldopa, penicilin

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8
Q

gray baby syndrome

A

chloramphenicol

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9
Q

hemolysis in G6PD pts

A

isoniazid, sulfanomies, primaquine, asprin, ibupropen, nitrofurantion

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10
Q

megaloblastic anemia

A

phenytoin, methotrexate, sulfa drugs

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11
Q

thrombotic compleations

A

OCPs

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12
Q

cough

A

ACEi

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13
Q

pulmonary fibrosis

A

bleomycin, amidodarone, busulfan

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14
Q

acute cholestatic hepatitis, jaundice

A

erythomycin

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15
Q

hepatic necrosis

A

halothane, mushroom poisoning, valproic acid, acetaminophen

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16
Q

hepatitis

A

INH

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17
Q

C diff infection

A

clindamycin, ampicillin

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18
Q

adrenal insufficnency

A

glucocortocoud withdrawal

19
Q

gynomasia

A

spirolactne, dig, cinetidine, EtOH chronic use, estrogens,ketoconazole

20
Q

hot flashes

A

tamifloxin, clomiphene

21
Q

hyperglycemia

A

niacin, tacrolimus, PIs, HCTZ, corticosteroids

22
Q

hypothyroudism

A

lithium, amiodarone, sulfanamides

23
Q

fat redistribution

A

glucosteroids, protease inhibitors

24
Q

gingival hyperplasia

A

phenytoin, verapamil

25
Q

gout

A

furosemide, thiazides, niacin, cyclosporin

26
Q

myopathies

A

fibrates, niacon, colchicine, hydroxychloroquinine, interferon-a, penicillamine, statins, glucosteroids

27
Q

osteoporosis

A

corticosteroids, heparin

28
Q

photosentitivity

A

sulfonamaides, amidarone, tetreacycline

29
Q

stevens-johnson (rash)

A

penicillin, ethosuximide, carbazapone, sulfa drugsm lamotrigine, allopurinol, pheytoin, phenobarbital

30
Q

SLE-like syndrome

A

hydralazine, INH, procanimide, phenytoin

31
Q

teeth problems in kids

A

tetracycline

32
Q

tendonitis

A

fluroquinolones

33
Q

diabetes insipidus

A

lithium, demeclocycline

34
Q

hamorrhagic cystitis

A

cyclophospamide, isofamide

35
Q

intersistital nephritis,

A

methicillin, NSAIDS, furosemide

36
Q

SIADH

A

carbamazepine, cyclophosphamide

37
Q

chinchoism

A

quinadine, quinidine (OD of asprin)

38
Q

serizues

A

Isoniazid, bupropion, imipemem/cilistatin, tramadol. enflurane, metoclopramide

39
Q

tardive dyskinesia

A

antipsychotics

40
Q

antimuscarinic

A

atropine, TCCA, H1-blockers, neuroleptics

41
Q

disulfram-like reaction

A

metronidazole, some cephlasporins, procarbazine, 1st gen sulfonylureas

42
Q

nephro-ototoxicity

A

aminoglycosides, vanco, loop diruretics, cisplatin

43
Q

P450 inducers

A
modafinil
barbos
St john's wort
phemytoin
rifampin
griseofulvin
carbamezepine
chronic EtOH use
44
Q

P450 inhibitors

A
macrolides
amiodarone
grapefruit juice
isoniazid, 
cimetidine
ritonavir,
acute EToH
cipro
ketoconazole
sulfanonamides
gemfibrozil
quinidine