general drug reactions

Question 1

can cause coronary vasospasm

Answer 1

cocaine, sumatriptan, ergot alkaloids

Question 2

skin flushing

Answer 2

vancomycin, adenosine, niacin, CCBs

Question 3

dilated cardiomypathy

Answer 3

doxorubicin, daunoribicin

Question 4

torsades de pointes

Answer 4

sotalol (class III antiarrythmic) and quinadine (class IA antiarythmic)

Question 5

agranulocytosis

Answer 5

clozapine, carbamazepine, colchine, propythiouracil, methimazole, dapsone

Question 6

aplastic anemia,

Answer 6

chloramphenicol, benzene, NSAIDS, proplythiouracil, methimazole

Question 7

direct coombs (+) hemolytic anemia,

Answer 7

methyldopa, penicilin

Question 8

gray baby syndrome

Answer 8

chloramphenicol

Question 9

hemolysis in G6PD pts

Answer 9

isoniazid, sulfanomies, primaquine, asprin, ibupropen, nitrofurantion

Question 10

megaloblastic anemia

Answer 10

phenytoin, methotrexate, sulfa drugs

Question 11

thrombotic compleations

Answer 11

OCPs

Question 12

cough

Answer 12

ACEi

Question 13

pulmonary fibrosis

Answer 13

bleomycin, amidodarone, busulfan

Question 14

acute cholestatic hepatitis, jaundice

Answer 14

erythomycin

Question 15

hepatic necrosis

Answer 15

halothane, mushroom poisoning, valproic acid, acetaminophen

Question 16

hepatitis

Answer 16

INH

Question 17

C diff infection

Answer 17

clindamycin, ampicillin

Question 18

adrenal insufficnency

Answer 18

glucocortocoud withdrawal

Question 19

gynomasia

Answer 19

spirolactne, dig, cinetidine, EtOH chronic use, estrogens,ketoconazole

Question 20

hot flashes

Answer 20

tamifloxin, clomiphene

Question 21

hyperglycemia

Answer 21

niacin, tacrolimus, PIs, HCTZ, corticosteroids

Question 22

hypothyroudism

Answer 22

lithium, amiodarone, sulfanamides

Question 23

fat redistribution

Answer 23

glucosteroids, protease inhibitors

Question 24

gingival hyperplasia

Answer 24

phenytoin, verapamil

Question 25

gout

Answer 25

furosemide, thiazides, niacin, cyclosporin

Question 26

myopathies

Answer 26

fibrates, niacon, colchicine, hydroxychloroquinine, interferon-a, penicillamine, statins, glucosteroids

Question 27

osteoporosis

Answer 27

corticosteroids, heparin

Question 28

photosentitivity

Answer 28

sulfonamaides, amidarone, tetreacycline

Question 29

stevens-johnson (rash)

Answer 29

penicillin, ethosuximide, carbazapone, sulfa drugsm lamotrigine, allopurinol, pheytoin, phenobarbital

Question 30

SLE-like syndrome

Answer 30

hydralazine, INH, procanimide, phenytoin

Question 31

teeth problems in kids

Answer 31

tetracycline

Question 32

tendonitis

Answer 32

fluroquinolones

Question 33

diabetes insipidus

Answer 33

lithium, demeclocycline

Question 34

hamorrhagic cystitis

Answer 34

cyclophospamide, isofamide

Question 35

intersistital nephritis,

Answer 35

methicillin, NSAIDS, furosemide

Question 36

SIADH

Answer 36

carbamazepine, cyclophosphamide

Question 37

chinchoism

Answer 37

quinadine, quinidine (OD of asprin)

Question 38

serizues

Answer 38

Isoniazid, bupropion, imipemem/cilistatin, tramadol. enflurane, metoclopramide

Question 39

tardive dyskinesia

Answer 39

antipsychotics

Question 40

antimuscarinic

Answer 40

atropine, TCCA, H1-blockers, neuroleptics

Question 41

disulfram-like reaction

Answer 41

metronidazole, some cephlasporins, procarbazine, 1st gen sulfonylureas

Question 42

nephro-ototoxicity

Answer 42

aminoglycosides, vanco, loop diruretics, cisplatin

Question 43

P450 inducers

Answer 43

``` modafinil barbos St john's wort phemytoin rifampin griseofulvin carbamezepine chronic EtOH use ```

Question 44

P450 inhibitors

Answer 44

``` macrolides amiodarone grapefruit juice isoniazid, cimetidine ritonavir, acute EToH cipro ketoconazole sulfanonamides gemfibrozil quinidine ```