GI-Pharm Flashcards
meds that work on the luminal side of stomach
misoprostol sucralfate bismuth antiacids (Tums) PPIs
meds that work on the apical side of the stomach
muscarinic antaginists
H2 blockers
octereotide (somatostatin)
SE of cimetidine
inhibitor of P450
anti-androgenic effects
can cross CNS and cause issues
H2 blockers that decrease renal excretion of creatine
cimetidine
rantidine
SE of PPI
increased risk of C diff and pnemonia, hip fractires
low Mg2+
MOA of bismuth and sucralfate
Bind to ulcer base, protecting and allowing HCO3- secetion to reestablish pH in mucous layer
use of bismuth and sucralfate
ulcer healing, traveler’s diaarhea
MOA of misoprostol
PGE1 analog, increases gastric mucous barrier and decreses acid production
Use of misprostol
prevent NSAID induced ulcers
maintains PDA
induces labor
misoprostol SE
diarreha
octreotide MOA
long acting somatostatin analoge
use of octreotide
acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors
Tox of octreotide
nausea, cramps, steatorrhea
antacid that causes constipation
Al salts
antiacid that causes diarreha
Mg salts (Must Go)
antacid that decreases chelates other drugs
calcium (especially Chelates TetraCycline)
GI drug that can be used to treat hepatic encephalopathy
Lactulose
MOA of infliximab
tnf-a monoclonal antibody
GI use of infliximab
crohn’s, ulceritive colitis, RA (cause, you know, immunospuressine)
MOA of sulfasalzine
combo of sulfapyrridine (antibiotic) and 5-amonosalicylic acid (anti-inflammatory)
use of sulfasalazine
UC, Crohn’s
tox ofsulfasalazine
malaise, nausea, sulonamide tox
ondanestron MOA
5-HT3 antagonist. Powerful central-acting antiemetic
use of ondanestron
postop n/v and chemo nausea
