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Step 1 - Pharm > GI-Pharm > Flashcards

GI-Pharm Flashcards

1
Q

meds that work on the luminal side of stomach

A 
misoprostol
sucralfate
bismuth
antiacids (Tums)
PPIs
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2
Q

meds that work on the apical side of the stomach

A

muscarinic antaginists
H2 blockers
octereotide (somatostatin)

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3
Q

SE of cimetidine

A

inhibitor of P450
anti-androgenic effects
can cross CNS and cause issues

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4
Q

H2 blockers that decrease renal excretion of creatine

A

cimetidine

rantidine

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5
Q

SE of PPI

A

increased risk of C diff and pnemonia, hip fractires

low Mg2+

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6
Q

MOA of bismuth and sucralfate

A

Bind to ulcer base, protecting and allowing HCO3- secetion to reestablish pH in mucous layer

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7
Q

use of bismuth and sucralfate

A

ulcer healing, traveler’s diaarhea

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8
Q

MOA of misoprostol

A

PGE1 analog, increases gastric mucous barrier and decreses acid production

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9
Q

Use of misprostol

A

prevent NSAID induced ulcers
maintains PDA
induces labor

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10
Q

misoprostol SE

A

diarreha

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11
Q

octreotide MOA

A

long acting somatostatin analoge

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12
Q

use of octreotide

A

acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors

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13
Q

Tox of octreotide

A

nausea, cramps, steatorrhea

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14
Q

antacid that causes constipation

A

Al salts

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15
Q

antiacid that causes diarreha

A

Mg salts (Must Go)

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16
Q

antacid that decreases chelates other drugs

A

calcium (especially Chelates TetraCycline)

17
Q

GI drug that can be used to treat hepatic encephalopathy

A

Lactulose

18
Q

MOA of infliximab

A

tnf-a monoclonal antibody

19
Q

GI use of infliximab

A

crohn’s, ulceritive colitis, RA (cause, you know, immunospuressine)

20
Q

MOA of sulfasalzine

A

combo of sulfapyrridine (antibiotic) and 5-amonosalicylic acid (anti-inflammatory)

21
Q

use of sulfasalazine

A

UC, Crohn’s

22
Q

tox ofsulfasalazine

A

malaise, nausea, sulonamide tox

23
Q

ondanestron MOA

A

5-HT3 antagonist. Powerful central-acting antiemetic

24
Q

use of ondanestron

A

postop n/v and chemo nausea

25
Q

metoclopramide MOA

A

D2 recptor antagonist, increses gastric motility, LES tone

26
Q

metroclopramide use

A

diabetic and post surgery gastroparesis, antiemetic

27
Q

Tox of metroclopramide

A

parkiinson like effects, interaction with dig and diabetic agents.

28
Q

metroclopramide contraindication

A

small bowel obstruction and/or parkinsons

Step 1 - Pharm (17 decks)

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