GI-Pharm

Question 1

meds that work on the luminal side of stomach

Answer 1

misoprostol
sucralfate
bismuth
antiacids (Tums)
PPIs

Question 2

meds that work on the apical side of the stomach

Answer 2

muscarinic antaginists
H2 blockers
octereotide (somatostatin)

Question 3

SE of cimetidine

Answer 3

inhibitor of P450
anti-androgenic effects
can cross CNS and cause issues

Question 4

H2 blockers that decrease renal excretion of creatine

Answer 4

cimetidine

rantidine

Question 5

SE of PPI

Answer 5

increased risk of C diff and pnemonia, hip fractires

low Mg2+

Question 6

MOA of bismuth and sucralfate

Answer 6

Bind to ulcer base, protecting and allowing HCO3- secetion to reestablish pH in mucous layer

Question 7

use of bismuth and sucralfate

Answer 7

ulcer healing, traveler’s diaarhea

Question 8

MOA of misoprostol

Answer 8

PGE1 analog, increases gastric mucous barrier and decreses acid production

Question 9

Use of misprostol

Answer 9

prevent NSAID induced ulcers
maintains PDA
induces labor

Question 10

misoprostol SE

Answer 10

diarreha

Question 11

octreotide MOA

Answer 11

long acting somatostatin analoge

Question 12

use of octreotide

Answer 12

acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors

Question 13

Tox of octreotide

Answer 13

nausea, cramps, steatorrhea

Question 14

antacid that causes constipation

Answer 14

Al salts

Question 15

antiacid that causes diarreha

Answer 15

Mg salts (Must Go)

Question 16

antacid that decreases chelates other drugs

Answer 16

calcium (especially Chelates TetraCycline)

Question 17

GI drug that can be used to treat hepatic encephalopathy

Answer 17

Lactulose

Question 18

MOA of infliximab

Answer 18

tnf-a monoclonal antibody

Question 19

GI use of infliximab

Answer 19

crohn’s, ulceritive colitis, RA (cause, you know, immunospuressine)

Question 20

MOA of sulfasalzine

Answer 20

combo of sulfapyrridine (antibiotic) and 5-amonosalicylic acid (anti-inflammatory)

Question 21

use of sulfasalazine

Answer 21

UC, Crohn’s

Question 22

tox ofsulfasalazine

Answer 22

malaise, nausea, sulonamide tox

Question 23

ondanestron MOA

Answer 23

5-HT3 antagonist. Powerful central-acting antiemetic

Question 24

use of ondanestron

Answer 24

postop n/v and chemo nausea

Question 25

metoclopramide MOA

Answer 25

D2 recptor antagonist, increses gastric motility, LES tone

Question 26

metroclopramide use

Answer 26

diabetic and post surgery gastroparesis, antiemetic

Question 27

Tox of metroclopramide

Answer 27

parkiinson like effects, interaction with dig and diabetic agents.

Question 28

metroclopramide contraindication

Answer 28

small bowel obstruction and/or parkinsons