reproductive pharm Flashcards
leuprolide MOA
GnRH analog with agonist properties when used in pulsitile fashion/antagonost when used continuously
use of leuprolide
infertility (pulsitile), prostatce cancer, uterine fibroids, precocious puberty
use of teststeroneas drug
hypogonadism and promotion of 2nd sex chaercteristics. stimulation of anabolism after burn/trauma
tox of testosterone therapy
masculinization in female, inhibits endogenous testosterone in males leading to gonadal atrophy. premature closure of epishyeal plates. bad cholesterol levels
use of finesteride
BPH, treats male pattern baldness
use f flutamide
prostatre cancer (competetive inhibitor of andogens at testosterone receptor)
use of ketoconaxole/spirolactone
PCOS tx
medical use of estrogens
hypogonasism or uterine failure, menstral abnormalities, HRT in postmenopausal women, men with androgen dependant prostate cancer
tox of estrogen therapy
risk of endometrial cancer, risk of kids vaginal cancer if exposed in utero, risk of thrombosis
contraindications of estrogen therapy
ER + breast cancer, hx of DVTs, smokers
SERMs
slomiphene, tamoxifen, raloxafine
use of clomiphene
stimulates ovulation,
SE of clomiphene
hot flashes, ovarian elnagrgment, twinning, visual disturbances
use of tamifoxen
treat and prevent recurrence of ER + breast cancer
use or raloxafine
osteoporosis
