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Step 1 - Pharm > pharm - endocrine > Flashcards

pharm - endocrine Flashcards

1
Q

MOA of insulin

A

bind TK insulin receptor

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2
Q

Metformin (Biguanide) effect

A

reduce glucogenesis, raise glycolysis and peripheral glucose uptake

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3
Q

metformin SE

A

GI upset - Lactic acidosis

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4
Q

tolbutamide, chlorproamide class

A

1st gen sulfonyllureas

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5
Q

glyburide, glimepride, glipizide class

A

2nd gen 1st gen sulfonyllureas

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6
Q

sulfonyllureas MOA

A

closes K+ channel in B-cell membranse, depolarizes and releases insulin

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7
Q

use of sulfonyllureas

A

stimulate endogenous release of insulin in DM2

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8
Q

SE of sulfonyllureas

A

1st gen - disulfram reaction

2nd gen - hypoglycemia

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9
Q

glitazone MOA

A

increases insulin sensitivity in peripheral tissue (binds to PPAR-g nuclear transcription regulator)

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10
Q

pramlintide use

A

lowers glucgon in type 1 and 2 DM

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11
Q

GLP-analogs

A

exenatide, liraglutide

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12
Q

exenatide, liraglutide use

A

increases insulin release, reduces glucagon release

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13
Q

acarbose/migitol

A

inhibit intestinal sugar hydrolysis and glucose absorption - effect is reduction in postprandial hyperglycemia

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14
Q

glitazone SE

A

weight gain, edema, hepatotox, heart failure

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15
Q

DPP-4 inhibitors

A

-gliptins

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16
Q

gliptin MOA

A

increases insulin release, reduces glucagon release

17
Q

gliptin SE

A

mild UTI/RTI

18
Q

GLP-1 analog SE

A

n/v, pancreatitis

19
Q

drugs for hyperthyroidism

A

propylthiouricil, methimazole

20
Q

propylthiouricil, methimazole MOA

A

block peroxidase, inhibiting organification of iodide and coupling of thyroid hormone syth. also blocks peripheral conversion of T3 to T4

21
Q

tox of propylthiouricil, methimazole

A

skin rash, agranulocytosis (rare), aplastic anemia, hepatotox (propyl) methimazole ppossible teratogen

22
Q

somatostatin use

A

acromegaly, carcinoid, gastrinoma, gluconoma, esophageal varices

23
Q

oxytocin use

A

stimulates labor, uterine contratcions, milk-let down. controls uterine hemmorrhage

24
Q

memeclocycine use

A

ADH antagonist (used in SIADH)

25
Q

tox of memeclocycine

A

nephrogenic DI, photosensitivity, abnormalities of bone and teeth

Step 1 - Pharm (17 decks)

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