pharm - onc Flashcards
vinca alkaloids and taxols effect what part of the cell cycle
M
antmetabolites effect what part of the cell cycle
S (DNA sythesis)
etoposide effects effect what part of the cell cycle
S (DNA synth) and G2 (synthesis of compenents needed for Mitosis)b
bleomycin effect what part of the cell cycle
G2 (synthesis of compenents needed for Mitosis)
drugs effecting thymidine synth
MTX, 5-FU,
drugs effecting purine synth
6-MP
drugs effecting DNA cross-linking
alkalyating agents, cisplatin
drugs that intercalate DNA
dactomycin, doxurubin
drugs that inhibit topoisomerase
etoposide
drugs that inhibit microtubule formatino
vinca alkaloids
drugs that inhibt microtubule dissaebmly
paclitaxel
MOA of MTX
folic acid analog - inhibts dihydrofolate reductace –>
effect of MTX
inhibits DNA and protein synth
use of MTX
blood cancers, choricocarcinomas
non cancer use of MTX
abortion, ectopic, RA, psoriasis
tox of MTX
myeosuppression, fatty liver, mucositis, birth defects
“rescue” of MTX
leucovorin
5-FU MOA
pyramidine analog converted to 5f-dUMP - complexes folic acid
effect of 5-FU
inhibits DNA and protein synth
use of 5-FU
colon cancer, basal cell carcinoma
tox of 5-FU
myleosuppression , photosensitivity
rescue of 5-FU
thymidine
MOA of cytarabine
pyramdine analog, inhibits DNA polymerase
use of cytarabine
blood cancers
tox of cytarabine
leukopenia, thrombocytopenia, megaloblastic anemia
6-MO/6-TG/azathrioprine MOA
purine anologs –> inhibit de novo purine synth
use of 6-MO/6-TG/azathrioprine
leukemia
6-MO/6-TG/azathrioprine tox
bone marrow, GI and liver tox
reacts with allopurinol
dactinomycin MOA
intercalates in DNA
use of dactinomycin
kids tumors
Tox od dactinomycin
myleosupression