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Step 1 - Pharm > pharm - onc > Flashcards

pharm - onc Flashcards

1
Q

vinca alkaloids and taxols effect what part of the cell cycle

A

M

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2
Q

antmetabolites effect what part of the cell cycle

A

S (DNA sythesis)

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3
Q

etoposide effects effect what part of the cell cycle

A

S (DNA synth) and G2 (synthesis of compenents needed for Mitosis)b

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4
Q

bleomycin effect what part of the cell cycle

A

G2 (synthesis of compenents needed for Mitosis)

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5
Q

drugs effecting thymidine synth

A

MTX, 5-FU,

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6
Q

drugs effecting purine synth

A

6-MP

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7
Q

drugs effecting DNA cross-linking

A

alkalyating agents, cisplatin

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8
Q

drugs that intercalate DNA

A

dactomycin, doxurubin

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9
Q

drugs that inhibit topoisomerase

A

etoposide

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10
Q

drugs that inhibit microtubule formatino

A

vinca alkaloids

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11
Q

drugs that inhibt microtubule dissaebmly

A

paclitaxel

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12
Q

MOA of MTX

A

folic acid analog - inhibts dihydrofolate reductace –>

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13
Q

effect of MTX

A

inhibits DNA and protein synth

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14
Q

use of MTX

A

blood cancers, choricocarcinomas

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15
Q

non cancer use of MTX

A

abortion, ectopic, RA, psoriasis

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16
Q

tox of MTX

A

myeosuppression, fatty liver, mucositis, birth defects

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17
Q

“rescue” of MTX

A

leucovorin

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18
Q

5-FU MOA

A

pyramidine analog converted to 5f-dUMP - complexes folic acid

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19
Q

effect of 5-FU

A

inhibits DNA and protein synth

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20
Q

use of 5-FU

A

colon cancer, basal cell carcinoma

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21
Q

tox of 5-FU

A

myleosuppression , photosensitivity

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22
Q

rescue of 5-FU

A

thymidine

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23
Q

MOA of cytarabine

A

pyramdine analog, inhibits DNA polymerase

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24
Q

use of cytarabine

A

blood cancers

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25
Q

tox of cytarabine

A

leukopenia, thrombocytopenia, megaloblastic anemia

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26
Q

6-MO/6-TG/azathrioprine MOA

A

purine anologs –> inhibit de novo purine synth

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27
Q

use of 6-MO/6-TG/azathrioprine

A

leukemia

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28
Q

6-MO/6-TG/azathrioprine tox

A

bone marrow, GI and liver tox

reacts with allopurinol

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29
Q

dactinomycin MOA

A

intercalates in DNA

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30
Q

use of dactinomycin

A

kids tumors

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31
Q

Tox od dactinomycin

A

myleosupression

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32
Q

doxirubicin MOA

A

generates free radicals, breaks DNA

33
Q

use of doxirubicin

A

solid tumors, blood cancers

34
Q

SE of doxirubicin

A

dilatated cardiomyopathy
myleosuppression
alopecia
can be toxic to exposed tissues

35
Q

used to chelate doxirubicin from heart

A

dexrazoxane

36
Q

bleolycin MOA

A

induces free radicals

37
Q

Bleomycin use

A

testicular cancer, hodgkin’s lymphoma

38
Q

bleomycin tox

A

pulmonanry fibrosis
skin changes
some myleosuppression

39
Q

cylcophosphamide MOA

A

interstrands DNA at guinine (must be activated by liver)

40
Q

use of cylcophosphamide

A

brain tumors

41
Q

SE of cylcophosphamide

42
Q

busulfan MOA

A

alklylates DNA

43
Q

busulfan use

A

CML (and ablates pts marrow before transplantation)

44
Q

Busulfan tox

A

pulmonary fibrosis

45
Q

vincristine/vinblastine MOA

A

bind to tubulin in M phase and blowck microtubules. mitoic spindle cannot form

46
Q

use of vincristine/vinblastine

A

solid tumors, blood cancer

47
Q

tox of vincristine

A

neurotox (areflexia,pripheral neutitis, paralytic ileus)

48
Q

tx of vinblastine

A

severe bone marrow suppression

49
Q

MOA of taxols

A

hyperstabalizes microtubules so the mitotic spindle cannot break down –> no anaphase

50
Q

use of taxols

A

ovarian and breast carcinoma

51
Q

tox of taxols

A

myleosuppression and hypersensitivity

52
Q

MOA of cisplatin/carboplatin

A

cross-links DNA

53
Q

use of cisplatin/carboplatin

A

testicular, bladder,ovary, and lung carcinomas

54
Q

tox of cisplatin/carboplatin

A

nephro.ototox

55
Q

prevent nephrotix in cisplatin/carboplatin with

A

amifostine ad chloride diuresis

56
Q

etoposide, teniposide MOA

A

inhibit topiisomerase II

57
Q

use of etoposide, teniposide

A

solid tumors, blood cancers

58
Q

tox of etoposide, teniposide

A

myleosuppression, GI irritation, alopecia

59
Q

hydroxyurea MOA

A

inhibits ribonucleotide reductase –> inhibits S phase DNA synthesis

60
Q

use of hydroxyurea

A

melanoma, CML, sickle cell

61
Q

tox of hydroxyurea

A

bone marrow suppression, GI upset

62
Q

cancer use of predisone

A

CLL, non-HL,

63
Q

tamoxifen MOA

A

SERM. Blocks estrogen binding in estrogen receptor + cells

64
Q

use of tamoxifen

A

breast cancer tx and prevention - also prevents osteoporosis

65
Q

tox of tamoxfen

A

can increase risk of endometrial cancer

66
Q

SERM that does in increase risk of endometrial cancer

A

raloxafine

67
Q

trastuzumab MOA

A

monoclonal antobody against HER-2

68
Q

use of trastuzumab

A

MER-2 + breast cancer

69
Q

tox of trastuzumab

70
Q

imatinb (Gleevec) MOA

A

philly chromosome TK inhibitor

71
Q

use of imatinb (Gleevec)

A

CML, GI stromal tumors

72
Q

tox of imatinb (Gleevec)

A

fluid retention

73
Q

rituximab MOA

A

monoclonal antobody against CD-20 on B cells

74
Q

use of rituximab

A

NHL, RA (with MTX)

75
Q

vemurafenib MOA

A

inhibis B-Raf kinase with v600E mutation

76
Q

vemurafenib use

A

metastatic melanoma

77
Q

bevacizumab MOA

A

monoclonal antibody against VEGF (inhibts angiogenesis)

78
Q

bevacizumab use

A

solid tumors

Step 1 - Pharm (17 decks)

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