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Step 1 - Pharm > pharm - immunomodulators > Flashcards

pharm - immunomodulators Flashcards

1
Q

cyclosporine MOA

A

binds to cycophilins

blocks differentiation and activation of T cells by binding to calcineurin

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2
Q

cyclosporin use

A

post transplantation anti rejection, some autoimmune dxs

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3
Q

cyclosporin tox

A

nephrotox, hypertension, hyperglycemia, tremor, gingival hyperplasia, tremor, hirsutism

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4
Q

tacrolimus tox

A

nephrotox, hypertension, hyperglycemia, tremor, tremor,

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5
Q

tacrolimus MOA

A

bids to FK-binding protiein, blocks differentiation and activation of T cells

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6
Q

tacrolimus use

A

potent antirejection

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7
Q

sirolimus/rapamycin MOA

A

inhibits mTOR, inhibits T cell proliferation in reponse to IL-2

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8
Q

sirolimus/rapamycin use

A

post transplant in kidney graft. Also in drug eluding stents

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9
Q

sirolimus/rapamycin tox

A

hyperlipidemia, thrombocytopenia, leukopenia

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10
Q

azathrioprine MOA

A

precursor to 6-mercaptopurine that interferes with metabolism and synthesis of nucleic acids

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11
Q

azathrioprine use

A

kidney transplant, autoimmune disorders

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12
Q

azathrioprine tox

A

bone marrow supression (increased by allopurinol)

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13
Q

muromonab-CD3 (OKT3) MOA

A

monoclonal antibidy that binds to and blocks CD3 on T cell

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14
Q

muromonab-CD3 (OKT3) use

A

immunosupression after kidney graft

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15
Q

muromonab-CD3 (OKT3) tox

A

cytokine release storm, hypersensitivity

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16
Q

use of aldesleukin (IL-2)

A

renal cell carcinoma, metastatic melanoma

17
Q

use of erythopestin

A

anemias (esp in renal failure)

18
Q

use of filgrastim

A

recovery of bone marrow

19
Q

use of sardramostim (Granulocyte-macrophage colony stimulating factor)

A

recovery of bone marrow

20
Q

use of a-interferon

A

hep B/C, KS, leukemia, melanoma

21
Q

use of B interferon

A

MS

22
Q

use of G-interferon

A

chronic granulomatous disease

23
Q

Oprelvekin (IL-11) use

A

thrombocytopenia

24
Q

use of thrombopeoiten

A

thrombocytopenia

25
Q

digoxin immune Fab use

A

digoxin OD

26
Q

infliximab use

A

(target’s TNF-a) crohn’s, RA, psoratic arthritis, ankylosing spondy

27
Q

adalimumab use

A

(target’s TNF-a) crohn’s, RA, psoratic arthritis, ankylosing spondy

28
Q

abiciximab use

A

targets gycoprotein IIb/IIIa - preents cardiac ischemia in unstable angina and in pts treated with PCI

29
Q

trastuzumab (herceptin) use

A

HER2 overexpressing breast cancer

30
Q

rituximab use

A

targets CD20 - B cell non-hodgkin’s lymphoma

31
Q

omalizumab use

A

targets IgE - severe asthma

Step 1 - Pharm (17 decks)

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