Reproductive Embryology Flashcards
source of gonads (as far as tissue and location)
thickened area of mesoderm develops on the medial side of mesonephros creating a bulge in week 5 — the gonadal ridge
indifferent gonads consist of
external cortex and internal medulla
in XX embryo, cortex _____ and medulla ____
in XY embryo, cortex ______ and medulla _____
forms ovaries; regresses
regresses; forms testes
gonads are indifferent until week ____
7
originate in the wall of the umbilical vesicle and migrate to gonadal ridges
primordial germ cells
primordial germ cells invest into the _____ and eventually form ____ or _____
gonadal cords
oocytes or sperms
directs gonad differentiaion
SRY gene for testis-determining factor (TDF)
TDF induces ________ to condense and extend into the medulla of the indifferent gonads, to form _______
gonadal cords
rete testis
thick, fibrous capsule that separates the gonadal cords from the surface
tunica albuginea
form interstitial (Leydig) cells that secrete androgen testosterone at week 8
Seminiferous tubules
where are sustenacular (Sertoli) cells and what do they do?
Seminiferous tubules
secrete mullerian inhibiting substance (MIS) aka antimullerian hormone
what does mullerian inhibiting substance do?
suppresses the formation of female structures
forms efferent ductules which eventually connect to ductus epididymis
rete testis
in ovary development, gonadal cords extend into medulla of ovary and form
rete ovarii
in ovary development, cortical cords extend from surface epithelium of developing ovary in to the underlying mesenchyme.
__________ move in.
cords create clusters called ________ which consists of an _______ surrounded by a singular layer of _________ from surface epithelium
active mitosis produces _________ before birth (many degenerate)
primordial germ cells
primordial follicles; oogonium; follicular cells
2 million primary oocytes
2 pairs of ducts in both male and female embryos
________ develop i male
________ develop in female
Mesonephric (Wolffian) ducts
Paramesonephric (Mullerian) ducts
in development of male genital ducts, fetal testes produce testosterone and MIS.
What do they do?
MIS - inhibits paramesonephric (Mullerian) duct formation
testosterone - stimulate mesonephric (Wolffian) duct formation
the mesonephric ducts are transformed into _____ and _______ and smooth muscle invests and forms
efferent ductules and duct of epididymis
ductus deferens
Three male glands
Seminal vesicle
prostrate gland
bulbourethral gland
lateral outgrowth from caudal end of each mesonephric duct forms
seminal vesicle