Lecture 3 - Tissue Flashcards
protein and carbohydrate material that cells produce on and in which they are supported (nonliving material)
Extracellular matrix
functions of ECM
structural support protection filtration nutrient and GF storage regulates cell movement and cell-cell interaction
ECM composed of (2)
ground substance - gel-like
fibers - withstand tensile forces
three components of ground substance
glycosaminoglycans (GAGs) - resist compression
proteoglycans - resist compression; facilitate normal cellular locomotion
glycoproteins - helps cells adhere to ECM
which are the most abundant ECM fibers?
collagen fibers
what is scurvy
lack of vitamin C causing collagen to not form properly
what is Ehlers-Danlos
abnormal cross-links resulting in hypermobile joints and hyperextensive skin
what is Keloid
excessive accumulation of collagen during wound healing
fibers that provide elasticity to stretch and recoil
elastic fibers
Marfan syndrome
elastic fibers don’t develop properly
structural/framework fibers (think mesh)
reticular fibers
a two-part acellular ECM structure that is between epithelium and adjacent connective tissue
basement membrane
two parts of basement membrane
basal lamina (outer/near epi) - molecular filter and path for cells
lamina reticularis (inner)
two types/divisions of epithelium
covering & lining epithelium - sheets of continuous cells
glandular epithelium - epithelial cells modified for secretion
what does it mean to say epithelial cells have polarity?
they have a specific orientation relative to other cells basal lamina
- apical surface - basolateral surface
apical surface of cell faces ______
basal surface of cell marks _______
lumen
boundary between epithelium and connective tissue
classification of covering & lining epithelium:
by number of layers (3)
simple - single layer
stratified - multiple layers; named after superficial layer
pseudostratified - single layer but nuclei are at different levels
classification of covering & lining epithelium:
by shape of cell (5)
squamous - flat, plate-like
cuboidal - cube-like; similar height and width
columnar - tall; height greater than width
transitional - pillow shaped
pseudostratified - tall but irregular shapes
simple squamous typically found in (3)
pulmonary alveoli
loop of Henle
Blood and lymph vessels
simple cuboidal typically found in (2)
ducts of many glands
urinary tubes