Reproductive Flashcards
Gono infection labs show:
Gram (-) Diplococci
Gono Tx
IM Ceftriaxone 250 mg +
PO Azithromycin 1 g
(can also use PO Doxy x 7d)
What procedure is done to help the odds of pregnancy in a patient with history of cervical incompetence and/or miscarriage?
Cervical Cerclage (stitch)
New onset HTN < 20 wks gestation, suspect _____.
Molar Pregnancy
What would labs show in ovarian torsion?
Leukocytosis (High WBC)
What is the GOLD standard for Dx of ovarian torsion?
Laparoscopy
RFs for Cervical Insufficiency:
- Ehlers-Danlos Syndrome (stretchy skin syndrome)
- Trauma to cervix
- Tx of cervical intraepithelial neoplasia
MCC of abnormal uterine bleeding in older, obese women
Endometrial Hyperplasia
Tumor marker for Ovarian CA ONLY
CA-125
PID Tx
IM Ceftriaxone + Doxycycline x 14d
Malodorous gray vaginal discharge. Dx?
Bacterial Vaginosis
BRCA -1 and BRCA-2 found in:
Breast and Ovarian CA
What is a Tocolytic?
Meds used to suppress premature labor. Uterine relaxant.
What is the Leopold maneuver?
PE maneuver used to help determine position of a fetus
What is the mgmt for Intrahepatic Cholestasis of Pregnancy?
Induce @ 36-37 wks.
What is a complication of Intrahepatic Cholestasis of Pregnancy?
Fetal demise.
Induce @ 36-37 wks. Demise usually >37wks.
Cycle length <21 d
Polymenorrhea
Preferred Abx for Mastitis
Dicloxacillin or Cephalosporins
Recommend continued breastfeeding with Mastitis to prevent:
Breast abscess
MC ovarian cyst
Follicular
Cycle length > 35d
Oligomenorrhea
What is the Disulfiram-like reaction?
- Flushing
- Tachycardia
- Hypotension
MCC Mastitis
Staph aureus
During menopause, what happens to estrogen and FSH levels?
- Estrogen decreases.
- FSH increases.
Mixing alcohol with Metronidazole causes:
Disulfiram-like reaction
HEAVY and prolonged mensuration
Menorrhagia
When do we give Rhogam?
28 wks
What diagnostic tests should be obtained 1st for ALL women of childbearing age presenting with pelvic complaints?
Urine beta-hCG (REGARDLESS of last period!)
Tx for Endometritis post C-section
Clindamycin + Gentamicin
With risks, when do we give Rhogam?
Within 72h onset of issues.
Risks: miscarriage, ectopic, trauma
Tx for Endometritis post natural delivery
Ampicillin + Gentamicin
MC non-viral STD in the world:
Trichomonas vaginalis
What is the initial lab for gestational diabetes screening?
1-hr glucose challenge test
Vaginal bleeding and/or pain, open os, products of conception within the cervical canal on exam.
Incomplete Abortion
Single dose SE of Azithromycin
Nausea
Early endometrial CA normally presents as:
Abnormal vaginal bleeding
> 50 yo presents to clinic with frequent urination and bloating. This presentation is MC in endometrial or ovarian CA?
Ovarian CA
Endometrial cancer Tx
Total hysterectomy and bilateral salpingo-oophorectomy (TAH-BSO)
Ectopic pregnancy Tx
Methotrexate (or Mifepristone) or surgery (laparoscopy)
What is the next step if OCPs are ineffective for AUB?
Ablation
In women with poorly controlled infection, severe symptoms, instability or wide spread nipple excoriation, what med HALTS lactation?
Cabergoline (dopamine agonist antagonizes the release of prolactin.)
All products of conception (POC) have passed, cervix is closed and the uterus is firm and non-tender.
Complete Abortion
Definition of gestational hypertension:
HTN without proteinuria or other SxS of preeclampsia that develops after 20 wks gestation.
Prevention of seizures during pregnancy:
Mg Sulfate
1st line pharmacotherapy for Premenstrual Syndrome:
SSRIs
MC RFs for BV:
- Vaginal pH > 4.5
- Frequent douching
- Pregnancy
- IUD
What is the biggest RF for ectopic pregnancy?
Hx of ectopic
MC patho of Endometrial CA
Adenocarcinoma
One-sided, LQ pain associated with normal ovulation.
Mittelschmerz
Dx TOC Leiomyoma
Transabdominal and Transvaginal US
Surgery used to remove leiomyomas with desired fertility:
Myomectomy
Prolactinoma Tx
Cabergoline
Recurring genital and oral ulcerations, relapsing uveitis. PE: necrotic center and surrounding red rim.
Behcet’s Syndrome
MC type of cervical cancer:
Squamous Cell Carcinoma
Sign for a blue cervix, normal during early pregnancy:
Chadwick’s Sign
Rx MC used to induce labor with favorable cervix:
Oxytocin
Primary syphilis infection Tx:
Penicillin G
Ideal intrapartum glycemic target for patients with gestational diabetes:
Fasting < 95mg/dL
After implantation, when is beta-hCG detectable?
7–8 days after fertilization
MC type and 2nd MC of vulvar CA:
1st: Squamous Cell Carcinoma
2nd: Melanoma
Vaginal bleed with OPEN os, NO POC
Inevitable Abortion
MC type of gynecological cancer:
Uterine CA
Dx for Endometriosis:
Laparoscopy
Perihepatitis + PID
Fitz-Hugh-Curtis Syndrome
Fetal heart patterns indicative of uteroplacental insufficiency:
Late decelerations
In women with an intact uterus, what HRT should never be given and why?
- Conjugated, unopposed estrogen.
- D/T risk of endometrial hyperplasia and carcinoma.
What is an appropriate therapy for a postmenopausal woman suffering from vaginal atrophy?
- Vaginal ring (2 mg Estradiol Q 3mo)
- Lube
- Moisturizers
Complication of preterm rupture of membranes:
Chorioamnionitis
What is HIGH risk for preeclampsia?
Autoimmune disease
What is the HELLP syndrome?
Severe form of preeclampsia characterized by:
- Hemolysis
- Elevated LFTs
- Low platelets
Is Metronidazole given during pregnancy?
Yes
What is the preferred diagnostic method for Placenta Previa?
Transvaginal US > Transabdominal
Tx for eclamptic seizures at any time period (before or after delivery):
Mg Sulfate
Is Azithromycin safe during pregnancy to treat Chlamydia?
Yes
1st line therapy for recurrent endometrial carcinoma:
HIGH dose Progestin
MC presenting symptom in a woman with vaginal cancer:
Vaginal bleed
MCC Bacterial Vaginosis
Decrease in Lactobacilli which leads to increase in Gardnerella vaginalis
New born infant that’s cyanotic, tachycardic, tachypneic, and noted to have generalized edema. Mother had no prenatal care. Dx?
Erythroblastosis fetalis (Rh+ with mom Rh-)
If 1st line Tx for Atrophic Vaginitis fails, what is the next step?
Vaginal estrogen
Does Progesterone help with lubrication or elasticity of vagina in Atrophic Vaginitis?
No
Painless, firm, solitary, mobile, slowly growing breast mass (DOES NOT change with cycles**). Dx?
Fibroadenoma
What type of breast cancer presents as eczematous, itchy, scaly lesion of nipple or areola?
Paget’s
Tx for Molar Pregnancy
Dilation and curettage
What are the MC causes of ovarian torsion? What are other RFs?
- MC Cyst or tumor (teratomas)
- Pregnancy, ovary >5cm
To assess fallopian tube patency, what procedure is done?
Hysterosalpingography
Tubo-ovarian Abscess vs. PID
Both have CMT but TOA has UNIlateral pain on palpation.
What is the mgmt for Premature Rupture of Membranes at 24 to 34 wks?
Give corticosteroids to mature lungs.
Pap smear results come back as CIN stage 2. What is the next step in mgmt?
Colpo
Tx for Bacterial Vaginosis besides Metro that can be used in pregnancy
Clinda
Dysmenorrhea, Dyspareunia (pain during sex), Dyschezia (painful bowel movement). Dx?
Endometriosis
Prenatal care: When is maternal alpha fetal protein measured?
16-18 wks
Expected lab results with primary ovarian failure
- ↑ FSH
- ↑ LH
- ↓ Estradiol
Dx for Endometrial Cancer
Transvag. US or Endometrial Bx (suction curette)
Colposcopy: white, sharply demarcated cervix after application of acetic acid. Dx?
Cervical dysplasia
1st line BC for adolescents
Etonogestrel Implant (L/A reversible contraception) or IUD
Two MC SEs of hormonal contraception
- Breakthrough bleeding
- Amenorrhea
Painful vulvar ulcers and swollen inguinal lymph node. Patho? Dx?
- Haemophilus ducreyi
- Chancroid
Condyloma lata is found in what STI?
Treponema pallidum (syphilis)
What home remedies can you give to a non-breast feeding postpartum female with a tender breast engorgement?
Supportive bra, cold cabbage leaves, ice packs.
In what scenarios is breastfeeding CI?
- HIV mom
- Type 1 Galactosemia
What phase of the menstrual cycle occurs at the time of the progesterone surge?
Luteal (Secretory)
-Corpus luteum secretes progesterone
What is the mgmt for Premature Rupture of Membranes at >34 wks?
Delivery
Dx for Tubo-ovarian Abscess
US
Tx for Primary Dysmenorrhea
NSAIDs (antiprostaglandin action)
Regular cycles that have xs flow and duration. Dx?
Menorrhagia
Adolescent females taking inj. Depo >2 yrs should be monitored for which SE?
Bone mineral density loss
What is a potential complications of undergoing surgical repair of a rectocele?
Dyspareunia (painful sex)
Is Gynecomastia in males during early pubertal changes normal?
Yes, reassure.
Complication of vaginal delivery that occurs when obstetrical maneuvers beyond gentle traction are needed to enable delivery of the fetal shoulders
Dystocia
What is a lab finding in Placental Abruption?
Hypofibrinogenemia
For HRT in a woman that has a uterus, what is the Tx?
Estrogen + progestin (prevent endometrial hyperplasia).
Tx for Breast CA
Lumpectomy, sentinel lymph node biopsy and radiation therapy
Extremely high levels of HCG. Dx?
Gestational trophoblastic disease
Fluctuating menstrual intervals and PE showing 1 ovary is appreciably larger than the other. Dx?
Functional ovarian cyst
Pt. presents to ED with a finger lac. She is 8 wks pregnant and has had 2 days of vaginal spotting and lower abdominal cramping. She has a closed os and no tenderness or masses on palpation (~possible threatened abortion or ectopic pregnancy). What is the mgmt?
Treat her laceration, perform hCG quantitative level and pelvic US
What is the definition of premature labor?
Labor < 37 wks
MC type of breast cancer
Infiltrating ductal (80%) > Infiltrating lobular (15%)
What meds are considered risk-reducing for women who are at an increased risk of breast cancer?
Tamoxifen and Raloxifene
When should Folic Acid be started in women?
Anyone that may become pregnant. At least 1 month before conception.
What is the MC cell type of ovarian cancer?
Epithelial
What phase of the menstrual cycle occurs at the time of the luteinizing hormone surge?
Ovulation
What 5 vaccines are safe in pregnancy?
- Hep B
- Flu (inactive)
- Tdap
- Meningococcal
- Rabies
When do mammo screenings start for breast cancer and how often?
50-74yo biennially
Tx for Ectopic Pregnancy that’s unstable
Laparoscopy
Fundal height 4cm higher than where it should be. Dx?
Multiple gestations
Tx for Preeclampsia
Mg Sulfate (prevent seizures)
Painless nodule in genital area that progresses to a painless ulcer with rolled borders that is highly vascular, with “beefy-red” appearance. Dx?
Granuloma inguinale (D/T Klebsiella granulomatis) -Common in India, Africa, Australia
Can NSAIDs be used during pregnancy?
No bc they are Prostaglandin-Inhibitors
A pregnant HIV positive patient presents to clinic. What med do you start and when?
Azidothymidine (AZT) @ 28 weeks.
Pap smear results come back as CIN stage 1. What is the next step in mgmt?
Repeat pap
What phase of the menstrual cycle occurs at the time of the estrogen surge?
Follicular (Proliferative)
31 yo presents for pap smear results. She has (+) HPV DNA test but (–) pap smear. What is the next step?
Repeat in 1 yr
At what age can women stop getting pap smears?
65 yo with Hx of THREE negative paps prior