Pharm

Question 1

Antipyretics

Answer 1

Ibuprofen and Aspirin.

Reduce fever.

Question 2

Meds that cause Ototoxicity

Answer 2

• Aminogylcosides: Genta, Tobra
• Loop diuretics: Furo, Bume
• Platinum-based chemo: Carbo, Cis

Question 3

CI to Pyridostigmine (acetylcholinesterase inhibitors )

Answer 3

Mechanical GI and urinary obstruction.

Question 4

Achilles tendon rupture risk increases when using what meds?

Answer 4

• Chronic steroid usage

- FQs

Question 5

MC SE of HGM-CoA Reductase Inhibitors

Answer 5

1st: Myalgias

Watch for Myopathy, Rhabdo

Question 6

Hydroxychloroquine: Monitor ____ every 6-12 mo

Answer 6

Eye exam

Question 7

DMARDs SE and monitor what?

Answer 7

• Bone marrow suppression

- CBCs

Question 8

What ECG finding is seen with Macrolide use?

Answer 8

QT prolongation

Question 9

Drug class MOA of “-pine” meds and how can we remember that for what they do?

Answer 9

• Dihydropyridine (DHP)

- “Don’t Hurt Pulse” → Don’t drop HR, only BP.

Question 10

Is it okay to use NSAIDs with renal issues?

Answer 10

No it’s CI bc they hold on to Na+ (thus, fluid retention) and they decreases blood supply (dec. renal prostaglandins).

Question 11

What should be monitored with a pt. on Olanzapine? Why?

Answer 11

• Lipid panel

- D/T hypercholesterolemia and DM

Question 12

What is monitored using Clozapine and why?

Answer 12

• WBC count

- Agranulocytosis (low WBC)

Question 13

Cymbalta (Duloxetine) indications

Answer 13

Nerve pain and depression

Question 14

What med is known to cause oropharyngeal candidiasis?

Answer 14

Fluticasone

Question 15

Immunosuppressive med that inhibits synthesis of guanine nucleotides → T and B lymphocytes inhibited from replicating.

Answer 15

Mycophenolate

Question 16

Common meds that have propylene glycol. What is a AE?

Answer 16

• Lorazepam, Diazepam
• Phenobarbital
• Phenytoin
• Nitroglycerin
• AE: dysrhythmias, hypoTN, bradycardia

Question 17

What antiepileptic med blocks neuronal Na+ channels to prolong the refractory period and inhibit action potential propagation?

Answer 17

Carbamazepine

Question 18

When do pts. on corticosteroids need to taper off to prevent adrenal insufficiency?

Answer 18

5-7 days

Question 19

What med is used in pt. with asthma and taking a pharm stress test?

Answer 19

Dobutamine

Question 20

What sedative med is CI with possible bowel obstruction?

Answer 20

Nitrous oxide

Question 21

What clinical Dx’s will increase the volume of distribution of hydrophilic meds?

Answer 21

Fluid retainers: Ascites, CKD, CHF

Question 22

MOA Allopurinol

Answer 22

Inhibits Xanthine Oxidase (enzyme that converts Hypoxanthine → Xanthine → Uric Acid)

Question 23

What receptor stimulates positive chronotropic and inotrope?

Answer 23

Beta 1

Question 24

Clonidine drug class

Answer 24

Alpha 2 agonist

Question 25

What causes Disulfiram-like reaction? What are the Sxs?

Answer 25

- EtOH + Metronidazole (or Bactrim) | - Severe flushing ± hypoTN and tachycardia

Question 26

Buprenorphine (opioid) is what kind of mu opioid receptor?

Answer 26

Partial agonist

Question 27

What toxicity is commonly associated with giving IV Amphotericin B?

Answer 27

Nephrotoxicity

Question 28

Which antiepileptic med requires dose adjustment for patients with hypoalbuminemia?

Answer 28

Phenytoin

Question 29

Anaphylaxis Sxs

Answer 29

Respiratory: Bronchospasms, wheezing, ↑ airway pressure which causes lower minute ventilation.

Question 30

What is used to ion trap aspirin in the urine thus enhancing elimination?

Answer 30

Sodium bicarbonate

Question 31

JNC8 guideline: How much time needs to pass before any adjustments to medication are made for HTN mgmt?

Answer 31

1 mo

Question 32

Procainamide adverse effect

Answer 32

Torsades

Question 33

MOA Ondansetron

Answer 33

Serotonin 3 (5HT3) receptor antagonist

Question 34

MC SE after giving IV Amiodarone

Answer 34

HypoTN

Question 35

What is monitored with chronic use of Amiodarone?

Answer 35

Annual CXR (D/T pulmonary toxicity)

Question 36

Albuterol can lead to what electrolyte abnormality?

Answer 36

HypoK

Question 37

What med causes SLE-like syndrome?

Answer 37

Isoniazid

Question 38

Med that aids with dry mouth in Sjogren’s syndrome

Answer 38

Pilocarpine

Question 39

What med causes severe angioedema?

Answer 39

ACE-I

Question 40

In what setting is dual antiplatelet therapy with aspirin and clopidogrel indicated?

Answer 40

After percutaneous coronary intervention and stent placement.

Question 41

What 2 need to be monitored for SEs of carbamazepine?

Answer 41

Hematologic (CBC) and hepatic (LFT).

Question 42

What is an SE of Daptomycin? What is checked bc of this?

Answer 42

- Myopathy and rhabdomyolysis | - Weekly monitoring of Creatine Phosphokinase

Question 43

In a lipophilic med, what clinical Dx will increase in the volume of distribution?

Answer 43

Obesity

Question 44

Which NSAIDs has the lowest risk of GI bleed?

Answer 44

Celecoxib

Question 45

What TB med is commonly associated with lupus-like syndrome?

Answer 45

Isoniazid

Question 46

Tx for Mg Sulfate Toxicity

Answer 46

Calcium Gluconate

Question 47

What meds causes Acute Tubular Necrosis?

Answer 47

Aminoglycosides (Genta)

Question 48

What antineoplastic med can cause cardiac toxicity and precipitate heart failure?

Answer 48

Doxorubicin

Question 49

What HTN med can cause hyperkalemia?

Answer 49

ACE-I

Question 50

Post-op fever on day 7+ would likely be D/T:

Answer 50

Medication induced

Question 51

Which med exerts its action by inhibiting cell wall synthesis?

Answer 51

Amoxicillin

Question 52

MOA ASA

Answer 52

Inhibits platelet aggregation by blocking cyclooxygenase-1 activity

Question 53

When can we use Levofloxacin as 1st line therapy?

Answer 53

Bounce-backs or Pseudomonas: - Ventilator in the ICU - Cystic fibrosis, COPD - Corneal abrasion D/T contact lens use - Plantar puncture wound through shoe - Malignant external otitis - DM