Neurology Flashcards
“Extrapyramidal symptom”: repetitive, abnormal, orofacial involuntary movements
Dyskinesia
In initial workup for polyneuropathy, what is done?
Electrodiagnostic (nerve conduction and EMG) before labs. (use the results of 1st to order labs)
PE test for Myasthenia Gravis
Ice test improves Sxs
What causes PD?
What does that produce?
- Degeneration of Lewy Bodies.
- Lewy bodies produce Dompaine.
Tx for Absence (Petit Mal) Seizure
EthoSUXimide
What is the MIDBRAIN part of and what is its function?
- Brainstem
- Controls eye movements
- Relays visual and auditory info
What is severely diminished with Alzheimer Disease (AD)?
Acetylcholine
Dx for Alzheimer Disease (AD) and what does it show?
- CT
- Cerebral Cortex Atrophy
PE finding in Guillain-Barre Syndrome
Loss DTR
Dx for Syringomyelia
MRI
1st line imaging to Dx Intracranial Hemorrhage
Non-contrast CT
What does Cerebellum do?
- Maintains posture and balance
- Coordinates voluntary movement
Brief LOC, blank stare, NO aura. Dx?
Absence (Petit Mal)
Cerebral Palsy cause:
Brain injury near time of birth.
Tx for Guillain-Barre Syndrome
- Plasmapheresis
- IVIG
Dx for Myasthenia Gravis
- (+) Ach receptor Antibodies
2. Edrophonium (Tensilon) test
TOC for Huntington Dz. and what does it show?
- CT
- Cerebral and Caudate nucleus atrophy.
Tx for Tourette Syndrome
-Dopamine blockers: Pimozide, Halo, Risperidone
Tx Restless Legs Syndrome
Dopamine agonist: Pramipexole, Ropinirole
CSF: HIGH protein, normal WBC. Dx?
Guillain-Barre Syndrome
Tx for Migraine and MOA
- Triptans or Ergos
- Serotonin 5HT-1 agonist → vasoconstrict
Pt. presents with diplopia and muscle weakness WORSE AT NIGHT and better with rest. Dx?
Myasthenia Gravis
Initial: 1) Behavioral (personality, intellect, psych) → 2) Chorea* 3) Dementia Dx?
Huntington Dz.
Tx for Myasthenia Gravis
- Acetylcholin-Esterase Inhibitors: Pyridostigmine or Neostigmine
- Acute: Plasmapheresis or IVIG (rapid response). Mechanical ventilation.
Confirmatory Dx for Multiple Sclerosis and what does it show?
- MRI T2-weighted (Gadolinium)
- White matter plaques (periventricular hyperdensities)
What does a LP show in Multiple Sclerosis?
- ↑ IgG (oligoclonal bands)
- ↑ WBC (pleocytosis)
Tx for Multiple Sclerosis
- Acute: IV Steroids > Plasmapheresis (if no response to steroids)
- Progressive: INF-B
Pt. presents with sudden onset of a weak face and inability to lift right eyebrow. Dx?
Bell Palsy
Sustained contraction (spasm) leading to twisting of body and abnormal posturing.
Dystonia
Tx for Trigeminal Neuralgia
1st: Carbamazepine
2nd: Gabapentin
Tx for Cluster HA and Prophy
1st: Oxygen
2nd: Triptans
Prophy: Verapamil
HA that presents with congestion, lacrimation, conjunctivitis:
Cluster
TOC for suspected concussion:
CT
Sudden onset confused state d/t identifiable cause (infxn, med)
Delirium
Tx for Alzheimer Disease (AD)
1) Ach-Esterase inhibitors: Donepezil
2) NMDA Agonist: Memantine
What is seen on imagining for Glioblastomas?
Variable ring of enhancement surrounded by edema.
What is seen on imagining for Meningiomas?
Intensely enhancing, well-defined lesion often attached to the dura.
-Motor deficits: Lower ext. > upper*.
-Sensory deficit: pain, temp, light touch
+/- Bladder dyfxn
Dx?
Anterior Cord
Initial TOC TIA
Head CT
MC hemorrhage in elderly and alcoholics and what does CT show?
- Subdural
- Concave (crescent-shaped)
CM: F/N/V/HA, chills → AMS, seizures.
(+) Kernig’s
(+) Brudzinski’s
Bacterial Meningitis
Cranial nerve function of voice, soft palate, gag reflex:
X (10) Vagus
1st: LOC → rigidity
2nd: repetitive jerking
3rd: coma/sleep
Dx?
Tonic-Clonic (Grand Mal)
Paresthesias of medial ankle down to foot arch involves ____ nerve.
Saphenous (L3-L4)
Which lobe of the brain controls hearing?
Temporal lobe
Teratogenic Antiepileptic drug:
Valproate
What is the next step with (–) CT but high suspicion of Subarachnoid Hemorrhage?
What does it show?
- LP
- Xanthochromia
Sudden onset of uni neck pain or HA around eye or frontal area, can be d/t chiropractor manipulation. Dx?
Carotid Artery Dissection
Phenytoin SE of chronic use and what electrolyte d/o does it cause?
- Gingival hyperplasia
- HypoCa+
CSF: HIGH protein, ↑ WBC, low Glucose, (+) PMN. Dx?
Bacterial Meningitis
Tx for Bacterial Meningitis >50 yo
Ceftriaxone + Vanco + Ampicillin (covers Listeria)