reproduction

Question 1

GnRH analog w/agonist properties when given pulsatile. antagonist when given continuously. decrease FSH/LH. use: infertility (pulsatile) prostate cancer, uterine fibroids, precocious puberty. SE: antiandrogen.

Answer 1

leuprolide

Question 2

bind estrogen receptors. use: hypogonadism or ovarian failure, menstrual anomalies. SE: endometrial cancer. clear cell adenocarcinoma (vagina), thrombus.

Answer 2

estrogens: ethinyl estradiol, DES, mestranol

Question 3

SERM. estrogen antagonist in hypothalamus. prevent neg feedback. increase LH/FSH release. stimulates ovulation. SE: hot flashes, multiple simultaneous pregnancies.

Answer 3

Clomiphene

Question 4

SERM. antagonist of estrogen in breast tissue. agonist in bone, and uterus. SE endometrial caner, thromboembolic events. ues: ER+ breast cancers.

Answer 4

tamoxifen

Question 5

SERM. agonist at bone, antagonist in uterus. SE increased rick of thromboembolic event. use: osteoporosis.

Answer 5

raloxifene

Question 6

Aromatase inhibitor used in postmenopausal women w/breast cancer (decrease estrogen).

Answer 6

Anastrozole, exemestane

Question 7

bind progesterone receptors. decrease growth and increase vascularization of endometrium. use: OCP, endometrial cancer,abnormal uterine bleeding.

Answer 7

progestins

Question 8

competitive inhibitor of progesterone receptors. use: termination of pregnancy. admin w/misoprostil.

Answer 8

Mifepristone

Question 9

Beta-2 agonist that relaxes the uterus. used to decrease contraction frequency in women during preterm labor.

Answer 9

Terbutaline

Question 10

synthetic androgen that acts a partial agonist at androgen receptor to decrease LH release (- feedback). use: endometriosis and hereditary angioedema.

Answer 10

Danazol

Question 11

Agonist at androgen receptor. use: hypogonadism, promotes devo of secondary sex characteristics. SE: masculinization in females, gonadal atrophy in men, premature epiphyseal plate closure.

Answer 11

Testosterone, methyltestosterone.

Question 12

5 alpha-reductase inhibitor (testosterone to DHT). use: BPH, male pattern baldness.

Answer 12

finasteride

Question 13

nonsteroidal competitive inhibitor of androgens at testosterone receptor. use: prostate cancer.

Answer 13

Flutamide

Question 14

inhibits steroid synthesis by inhibiting 17,20-desmolase. treat hirsutism in polycystic ovarian syndrome. SE: gynecomastia and amenorrhea.

Answer 14

Ketoconazole

Question 15

inhibits steroid binding, 17,20-desmolase and 17-hydroxylase.. treat hirsutism in polycystic ovarian syndrome. SE: gynecomastia and amenorrhea.

Answer 15

spironolactone

Question 16

alpha-1 antagonist. inhibits smooth muscle contraction in prostate. treat BPH (allow voiding).

Answer 16

tamsulosin

Question 17

PDE5 inhibitor causing increase cGMP, smooth muscle relaxation in corpus cavernosum. use: erectile dysfunction. SE: blue-green color vision, hypotension w/nitrates.

Answer 17

Sildenafil, vardenafil