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Pharm > Immunosuppressants > Flashcards

Immunosuppressants Flashcards

1
Q

Calcineurin inhibitor. binds cyclophilin. Blocks T-cell activation by preventing IL-2 transcription. prevent transplant rejection. Nephrotoxic.

A

Cyclosporine

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2
Q

Calcineurin inhibitor. binds FKBP. Blocks T-cell activation by preventing IL-2 transcription. prevent transplant rejection. Nephrotoxic and increase risk of diabetes.

A

Tacrolimus

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3
Q

mTOR inhibitor. binds FKBP. Blocks T-cell activation and B-cell differentiation by preventing IL-2 signal transduction. Kidney transplant rejection. non-nephrogenic.

A

Sirolimus (Rapamycin)

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4
Q

mAb. blocks IL-2R. kidney transplant rejection prophylaxis. Edema, HTN, tremor.

A

Basiliximab

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5
Q

antimetabolite precursor to 6-MP. block purine (A,G) synthesis. inhibit lymphocyte proliferation. transplant rejection and auto-immune. Myelosuppression.

A

Azathioprine

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6
Q

inhibit NF-xB. block cytokine transcription (both T and B-cells). transplant rejection, autoimmune, inflammation. Cushing-like syndromes

A

Glucocorticoids

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7
Q

Epoetin alfa (APO)

A

treat anemia

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8
Q

Thrombopoietin

A

treat thrombocytopenia

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9
Q

Oprelvekin (IL-2)

A

treat thrombocytopenia

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10
Q

Filgrastim

A

granulocyte colony stimulating factor. Recovery of bone marrow.

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11
Q

Sargramostim

A

granulocyte-macrophage colony stimulating factor. recovery of bone marrow.

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12
Q

Aldesleukin

A

IL-2. Treat renal cell carcinoma, metastatic melanoma

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13
Q

IFN-alpha

A

treat Chronic Hep B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminata, renal cell carcinoma, malignant melanoma.

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14
Q

IFN-beta

A

treat Multiple sclerosis

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15
Q

IFN-gamma

A

treat Chronic granulomatous disease

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16
Q

mAb against CD52. treats CLL

A

Alemtuzumab

17
Q

mAb against VEGF. treat colorectal cancer, renal cell carcinoma.

A

Bevacizumab

18
Q

mAb against EGFR. treat Stage 4 colorectal cancer, head and neck cancer.

A

Cetuximab

19
Q

mAb against CD20. treat B-cell non-Hodgkin lymphoma, RA, ITP

A

rituximab

20
Q

mAb against HER2/neu. treat breast and gastric cancer.

A

trastuzumab

21
Q

mAb against TNF-alpha. treat IBD, RA, ankylosing spondylitis, psoriasis.

A

Infliximab, adalimumab

22
Q

mAb against alpha4-integrin (leukocyte adhesion). treat MS, Crohn’s.

A

Natalizumab

23
Q

mAb against Glycoprotein 2b/3a. anti=platelet agent for prevention of ischemic complications of percutaneous coronary intervention.

A

abciximab

24
Q

mAb against RANKL. treat osteoporosis. inhibits osteoclast maturation.

A

Denosumab

25
Q

mAb against digoxin. anti-dote for digoxin toxicity.

A

Digoxin immune Fab

26
Q

mAb against IgE. treat allergic asthma. PRevents IgE from binding FceRI

A

Omalizumab

27
Q

mAb against RSV F protein. RSV prophylaxis for high risk infants.

A

Palivizumab

Pharm (17 decks)

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