Anti-fungal

Question 1

Binds ergosterol creating membrane pore. Serious systemic mycoses. Supplement K+ and MG2+

Answer 1

Amphotericin B

Question 2

binds ergosterol. only topical (too harsh). thrush, diaper rash, vaginal candidiasis.

Answer 2

Nystatin

Question 3

bind P-450 that converts lanosterol to ergosterol. local, less systemic mycoses.

Answer 3

azoles

Question 4

Azole. chronic crytococcus meningitis in AIDS, candida of all types

Answer 4

Fluconazole

Question 5

Azole. BLasto, Histo, Coccidioides.

Answer 5

Itraconazole

Question 6

Azole. topical fungal.

Answer 6

Clotrimazole and miconazole.

Question 7

converted to 5-flourouracil by cytosine deaminase. inhibit RNA and DNA synth. systemic fungal w/AmphoB

Answer 7

flucytosine

Question 8

inhibit synthesis of Beta-glucagon and thus cell wall. Invasive aspergilloisis and Candida

Answer 8

echinocandins: Caspofungin, micafungin

Question 9

inhibit squalene epoxidase. Dermatophyoses, especially onychomycosis

Answer 9

Terbinafine

Question 10

interferes w/microtubule formation, disrupts mitosis. oral treatment of superficial infect (dermatophytes)

Answer 10

Griseofulvin

Question 11

blocks detoxification of heme which accumulates and is toxic to plasmodium. Plasmodium other than falciparum.

Answer 11

Chloroquine

Question 12

Plasmodium falciparum

Answer 12

artemether/lumefantrine or atovaquone/proguanil

Question 13

mebendazole, pyrantel pamoate, ivermectin, diethylcarbamazine, parziquantel

Answer 13

anti-helminth

Question 14

Primethamine, suramin, melarsoprol, nifurtimox, sodium stibogluconate

Answer 14

anti-protozoan