Repro drugs

Question 1

OvSynch protocol in cattle?

Answer 1

1. Give GNRH
2. Wait 7 days
3. Give PG (prostaglandin)
4. Wait 2 days
5. Give GNRH again
6. Wait 24 hrs
7. Do AI

Question 2

Which drug is used for superovulation in horses?

Answer 2

eCG - equine chorionic gonadotropin

**mixed LH and FSH activity, FSH predominates

Question 3

Which drug is used for superovulation in cattle?

Answer 3

FSH

Question 4

Which drug is used to prevent ovulation?

Answer 4

1. progesterone
   -prevents LH surge
2. PRID (progesterone releasing vaginal device) in cattle

Question 5

Main use of megestrol acetate?

Answer 5

Used to prevent or postpone estrus in dogs

• also used to tx prostatic hyperplasia (dec. LH = dec. testosterone)
• Skin conditions in cats

Question 6

Side effects of megestrol acetate use in dogs?

Answer 6

Cystic endometrial hyperplasia - pyometra

Question 7

Main use of mibolerone?

Answer 7

Active androgen used to prevent estrus in dogs

Question 8

Side effects of mibolerone use on female dogs?

Answer 8

Female fetuses become masculinized

Question 9

Dopamine affect on reproduction?

Answer 9

Dopamine agonist Inhibits GNRH and prolactin

Question 10

What drug is used to increase GNRH and advance reproductive season in horses?

Answer 10

Domperidone (Dopamine antag)

Sulpiride

Question 11

Main use and MOA of cabergoline?

Answer 11

Dopamine agonist

• used to terminate pregnancy in dogs (ideally < 25 days)

Question 12

Main use of altrenogest in horses?

Answer 12

Suppress signs of estrus, used to support pregnancy

Question 13

Which drug is used to induce estrus in pigs?

Answer 13

GNRH

Question 14

Which drug is used to synchronize estrus in pigs?

Answer 14

Altrenogest

Question 15

Main use of estrogen during repro?

Answer 15

Supports pregnancy in horses

Question 16

Drugs used to induce parturition in horses?

Answer 16

Oxytocin

Question 17

Drug used to induce parturition in cows and sheep?

Answer 17

Corticosteroids

Question 18

Drug used to induce parturition in goats and pigs?

Answer 18

PGF2a

Question 19

Drug used to inhibit lactation in dogs in false pregnancy?

Answer 19

Cabergoline (Dopamine agonist)

Question 20

Drug used to induce lactation?

Answer 20

Domperidone (dopamine antagonist)

Question 21

Main use and MOA of finasteride?

Answer 21

5-alpha reductase inhibitor

Prevents conversion of testosterone

• Tx of benign prostatic hyperplasia

Question 22

Main use and MOA of flutamide?

Answer 22

Blocks dihydrotestosterone receptors

• Used to tx benign prostatic hyperplasia

Question 23

Side effects of prostaglandins when used to inhibit luteolysis?

Answer 23

• none in cattle
• Sweating and colic in horses
• Vascular ischemia in dogs

Question 24

Main use of hCG?

Answer 24

LH activity!

used to induce ovulation

Question 25

Drug used to induce ovulation in fish?

Answer 25

GNRH

Question 26

GNRH is used to induce estrus in which species?

Answer 26

Dogs and pigs

Question 27

GNRH is used to induce ovulation in which species?

Answer 27

Cattle, horses, fish