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pharm II > Cardiac Stimulants > Flashcards

Cardiac Stimulants Flashcards

1
Q

MOA of theophylline?

A

Phosphodiesterase (PDE) inhibitor

  • increases cAMP which increases contraction
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2
Q

Main use of theophylline?

A

Bronchodilation

  • chronic bronchitis and cough

not used for asthma

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3
Q

_________ is the toxic principal in chocolate

A

Theobromide

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4
Q

List the cardiac stimulants with the MOA of inhibiting phosphodiesterase

A
  1. Theophylline
  2. Aminophylline
  3. Theobromide
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5
Q

_________ is a diabetogenic used to treat insulinoma

A

Glucagon

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6
Q

What is the DOC for treatment of calcium channel blocker toxicity?

A

Glucagon

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7
Q

What cardiac stimulant is used to treat severe hyperkalemia?

A

Calcium salts (Calcium gluconate)

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8
Q

What is the DOC for treatment of CHF due to DCM or MVD?

A

Pimobendan

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9
Q

When is use of pimobendan contraindicated?

A
  • Aortic stenosis
  • HCM
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10
Q

What is the most common side effect seen with cardiac stimulants?

A

GI signs

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11
Q

MOA of digoxin?

A

Na/K ATPase inhibitor resulting in increased intracellular calcium

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12
Q

Cardiovascular effects of digoxin?

A
  • Positive ionotrope
  • Negative chronotropy and dromotropy
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13
Q

What drug is best for patients with bronchoconstriction?

A

Theophylline

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14
Q

________ is the most commonly used catecholamine for treatment of CHF due to myocardial failure

A

Dobutamine (B1 Agonist)

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15
Q

Clinical uses for digoxin?

A
  1. Atrial fibrillation
  2. CHF (pimobendan is 1st line DOC)
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16
Q

Digoxin has a _______ safety margin

A

Narrow

17
Q

What electrolyte imbalance can be seen with chronic use of digoxin?

A

HYPOkalemia

  • can cause cardiac tachyarrhythmias
18
Q

Digoxin has a ______ half life

A

long

19
Q

What electrolyte imbalance can be seen with acute use of digoxin?

A

HYPERkalemia

20
Q

Pimobendan has a _______ half life

A

Short, BID to TID dosing

21
Q

_________ is a positive iontrope and balanced vasodilator

A

Pimobendan

22
Q

MOA of pimobendan?

A

Phosphodiesterase III inhibitor

pharm II (23 decks)

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