Cardiac Stimulants Flashcards
MOA of theophylline?
Phosphodiesterase (PDE) inhibitor
- increases cAMP which increases contraction
Main use of theophylline?
Bronchodilation
- chronic bronchitis and cough
not used for asthma
_________ is the toxic principal in chocolate
Theobromide
List the cardiac stimulants with the MOA of inhibiting phosphodiesterase
- Theophylline
- Aminophylline
- Theobromide
_________ is a diabetogenic used to treat insulinoma
Glucagon
What is the DOC for treatment of calcium channel blocker toxicity?
Glucagon
What cardiac stimulant is used to treat severe hyperkalemia?
Calcium salts (Calcium gluconate)
What is the DOC for treatment of CHF due to DCM or MVD?
Pimobendan
When is use of pimobendan contraindicated?
- Aortic stenosis
- HCM
What is the most common side effect seen with cardiac stimulants?
GI signs
MOA of digoxin?
Na/K ATPase inhibitor resulting in increased intracellular calcium
Cardiovascular effects of digoxin?
- Positive ionotrope
- Negative chronotropy and dromotropy
What drug is best for patients with bronchoconstriction?
Theophylline
________ is the most commonly used catecholamine for treatment of CHF due to myocardial failure
Dobutamine (B1 Agonist)
Clinical uses for digoxin?
- Atrial fibrillation
- CHF (pimobendan is 1st line DOC)
Digoxin has a _______ safety margin
Narrow
What electrolyte imbalance can be seen with chronic use of digoxin?
HYPOkalemia
- can cause cardiac tachyarrhythmias
Digoxin has a ______ half life
long
What electrolyte imbalance can be seen with acute use of digoxin?
HYPERkalemia
Pimobendan has a _______ half life
Short, BID to TID dosing
_________ is a positive iontrope and balanced vasodilator
Pimobendan
MOA of pimobendan?
Phosphodiesterase III inhibitor
