Autocoids: Antihistamines and other Allergy drugs Flashcards
What is the MOA of Oclacitinib?
- JAK 1 and JAK 3 inhibitor
- IL31 inhibitor, blocks pruritis
Which of the following antihistamine does NOT cross the BBB?
A. Diphenhydramine
B. Meclizine
C. Hydroxyzine
D. Cetirizine
D. Cetirizine (2nd gen, non-drowsy)
What is not an adverse effect of antihistamines?
A. Sedation
B. CNS depression
C. Salivation
D. Increased IOP
C. Salivation
causes dry mouth (xerostomia)
_________ is rapidly metabolized to cetirizine in dogs
Hydroxyzine
Which of the following antihistamines has both sedative and antiemetic effects?
A. Diphenhydramine
B. Meclizine
C. Hydroxyzine
D. Cetirizine
B. Meclizine
Which of the following antihistamines is best used to treat motion sickness and vestibular disease?
Meclizine
What adverse effects can be seen with Oclacitinib use?
(Apoquel)
- GI signs
- Polydipsia
- Lethargy
- Risk of opportunistic infections
What is the MOA of Lokivetmab?
(Cytopoint) USDA biological agent
- Monoclonal AB that blocks IL31
List the 1st gen antihistamines
- Diphenhydramine
- Hydroxyzine
- Meclizine
List the 2nd gen antihistamines
- Cetirizine
- Loratadine
What is the main clinical indication for use of Diphenhydramine?
- DOC for allergic rxns (hives, facial swelling, wheals)
- Tx of Type 1 hypersensitivity
What is the main clinical indication for use of Lokivetmab?
(Cytopoint)
- Allergic and atopic dermatitis in DOGS only
What is the MOA of Diphenhydramine?
Competitive H1 antagonist
Which of the following is a Janus kinase inhibitor used to treat pruritis in dogs?
Oclacintinib (Apoquel)
What is the MOA of Hydroxyzine?
Competitive H1 antagonist
