Behavior Modifying Drugs Flashcards
What is the MOA of Reserpine?
Indirect sympatholytic, blocks NE uptake
What adverse effect can be seen with Reserpine use?
Hypotension
What is the main use of Reserpine?
Long acting tranquilizer to calm horses
(long term stall rest, mare aggression)
What is the MOA of Buspirone?
- Partial serotonin agonist
- Central dopamine antagonist
- Non-benzo anti-anxiety drug
What is the main clinical indication for use of Buspirone?
Used in cats to treat urinary marking and spraying behaviors
Which of the following can cause increased aggressiveness towards other cats in the household?
A. Reserpine
B. Buspirone
C. Fluoxetine
D. Trazadone
B. Buspirone
What is the main adverse effect that can be seen with Buspirone use in cats?
increased aggressiveness towards other cats in the household
What is the MOA of fluoxetine?
SSRI, inhibits reuptake of serotonin and upregulates GABA receptors
Which of the following can be used to treat lick granulomas?
A. Reserpine
B. Buspirone
C. Fluoxetine
D. Trazadone
C. Fluoxetine
What are the main uses of fluoxetine?
- Seperation anxiety
- Dominance aggression
- Tx of lick granulomas
- Inappropriate urination in cats
What is the MOA of Trazadone?
SARI, Serotonin antagonist reuptake inhibitor
- Blocks 5-HT2A and a1 adrenergic receptors
- Increases serotonin in the brain by blocking reuptake
Which of the following is used with caution in male breeding dogs due risk of causing priapism (prolonged erection)?
A. Reserpine
B. Buspirone
C. Fluoxetine
D. Trazadone
D. Trazadone
What is the MOA of Clomipramine?
Inhibits serotonin and NE reuptake
What is the MOA of Amitriptyline?
Inhibits serotonin and NE reuptake
What is the DOC to treat feather picking in birds?
Clomipramine or Amitriptyline
List the tricyclic antidepressants
- Clomipramine
- Amitriptyline
What adverse effects can be seen with use of Clomipramine or Amitriptyline?
- Narrow therapeutic index
- Cats more sensitive
- Lowers T4 and FT4
- Decreased seizure threshold
What drugs can be used to treat serotonin syndrome?
Serotonin antagonists
- Cyproheptadine
- Chlorpromazine
- IV lipid emulsion
Concurrent use of a selective serotonin reuptake inhibitor (SSRI) with which of the following drugs may lead to risk of serotonin syndrome?
A. Gabapentin
B. Tramadol
C. Lokivetmab
D. Diphenhydramine
B. Tramadol
Which of the following has a higher risk of toxicity even at therapeutic doses?
A. SSRIs
B. TCAs
B. TCAs
(Clomipramine and Amitriptyline)
Which of the following may increase the risk of serotonin syndrome?
A. Concurrent use of a hepatic enzyme inducer
B. Concurrent use of a hepatic enzyme inhibitor
C. Hepatic metabolic induction or inhibition will have little effect on serotonergic drug metabolism
B. Concurrent use of a hepatic enzyme inhibitor
-Inhibits metabolism of SSRIs and TCAs
Which of the following would NOT be used to treat serotonin syndrome?
A. IV lipid emulsion
B. Cetrizine
C. Cyproheptadine
D. Chlorpromazine
B. Cetrizine
What adverse effect can be seen with concurrent use of Tramadol and Trazadone?
Serotonin syndrome
(Both SSRIs)
