Behavior Modifying Drugs

Question 1

What is the MOA of Reserpine?

Answer 1

Indirect sympatholytic, blocks NE uptake

Question 2

What adverse effect can be seen with Reserpine use?

Answer 2

Hypotension

Question 3

What is the main use of Reserpine?

Answer 3

Long acting tranquilizer to calm horses

(long term stall rest, mare aggression)

Question 4

What is the MOA of Buspirone?

Answer 4

• Partial serotonin agonist
• Central dopamine antagonist
• Non-benzo anti-anxiety drug

Question 5

What is the main clinical indication for use of Buspirone?

Answer 5

Used in cats to treat urinary marking and spraying behaviors

Question 6

Which of the following can cause increased aggressiveness towards other cats in the household?

A. Reserpine
B. Buspirone
C. Fluoxetine
D. Trazadone

Answer 6

B. Buspirone

Question 7

What is the main adverse effect that can be seen with Buspirone use in cats?

Answer 7

increased aggressiveness towards other cats in the household

Question 8

What is the MOA of fluoxetine?

Answer 8

SSRI, inhibits reuptake of serotonin and upregulates GABA receptors

Question 9

Which of the following can be used to treat lick granulomas?

A. Reserpine
B. Buspirone
C. Fluoxetine
D. Trazadone

Answer 9

C. Fluoxetine

Question 10

What are the main uses of fluoxetine?

Answer 10

1. Seperation anxiety
2. Dominance aggression
3. Tx of lick granulomas
4. Inappropriate urination in cats

Question 11

What is the MOA of Trazadone?

Answer 11

SARI, Serotonin antagonist reuptake inhibitor

• Blocks 5-HT2A and a1 adrenergic receptors
• Increases serotonin in the brain by blocking reuptake

Question 12

Which of the following is used with caution in male breeding dogs due risk of causing priapism (prolonged erection)?

A. Reserpine
B. Buspirone
C. Fluoxetine
D. Trazadone

Answer 12

D. Trazadone

Question 13

What is the MOA of Clomipramine?

Answer 13

Inhibits serotonin and NE reuptake

Question 14

What is the MOA of Amitriptyline?

Answer 14

Inhibits serotonin and NE reuptake

Question 15

What is the DOC to treat feather picking in birds?

Answer 15

Clomipramine or Amitriptyline

Question 16

List the tricyclic antidepressants

Answer 16

1. Clomipramine
2. Amitriptyline

Question 17

What adverse effects can be seen with use of Clomipramine or Amitriptyline?

Answer 17

• Narrow therapeutic index
• Cats more sensitive
• Lowers T4 and FT4
• Decreased seizure threshold

Question 18

What drugs can be used to treat serotonin syndrome?

Answer 18

Serotonin antagonists
- Cyproheptadine
- Chlorpromazine
- IV lipid emulsion

Question 19

Concurrent use of a selective serotonin reuptake inhibitor (SSRI) with which of the following drugs may lead to risk of serotonin syndrome?

A. Gabapentin
B. Tramadol
C. Lokivetmab
D. Diphenhydramine

Answer 19

B. Tramadol

Question 20

Which of the following has a higher risk of toxicity even at therapeutic doses?

A. SSRIs
B. TCAs

Answer 20

B. TCAs

(Clomipramine and Amitriptyline)

Question 21

Which of the following may increase the risk of serotonin syndrome?

A. Concurrent use of a hepatic enzyme inducer
B. Concurrent use of a hepatic enzyme inhibitor
C. Hepatic metabolic induction or inhibition will have little effect on serotonergic drug metabolism

Answer 21

B. Concurrent use of a hepatic enzyme inhibitor

-Inhibits metabolism of SSRIs and TCAs

Question 22

Which of the following would NOT be used to treat serotonin syndrome?

A. IV lipid emulsion
B. Cetrizine
C. Cyproheptadine
D. Chlorpromazine

Answer 22

B. Cetrizine

Question 23

What adverse effect can be seen with concurrent use of Tramadol and Trazadone?

Answer 23

Serotonin syndrome

(Both SSRIs)