Muscle Relaxants Flashcards
1
Q
List the peripheral muscle relaxants
A
- Dantrolene
2
Q
List the centrally acting muscle relaxants?
A
- Methocarbamol
- Guaifenasin
Others: Benzodiazepines, Phenothiazines
3
Q
Which of the following does not cross the BBB?
A. Dantrolene
B. Methocarbamol
C. Guaifenasin
A
A. Dantrolene
4
Q
Dantrolene is the DRUG OF CHOICE for treatment of ____________
A
Malignant hyperthermia (idiosyncratic drug reactions leading to rhabdomyolysis)
5
Q
Infection with ________ can be treated with Dantrolene
A
Tetanus
- Decreases muscle rigidity, spasms, and sympathetic tone
50% mortality despite best treatment
6
Q
What is the MOA of Dantrolene?
A
Peripherally acting muscle relaxant
- Interferes with release of Calcium from SR by binding to RYR1 ryanodine receptor
7
Q
MOA of Methocarbamol?
A
Centrally acting muscle relaxant
- Blocks nerve impulse transmission in the spinal cord
8
Q
Methocarbamol has a _____ half time
A
Short
9
Q
Methocarbamol has rapid ______ absorption
A
Oral
10
Q
How can methocarbamol be administered?
A
Oral or IV
- Oral more common due being less expensive
11
Q
Clinical uses for Methocarbamol?
A
- IVDD
- Tetanus
- Intoxication (tremorogenic)
