Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

pharm II > Drugs acting on Coagulation > Flashcards

Drugs acting on Coagulation Flashcards

1
Q

Which of the following helps with blood clot formation?

A. Low dose Aspirin
B. Warfarin
C. Vitamin K
D. Clopidogrel

A

C. Vitamin K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

List the anti-thrombotics

A
  1. Low dose Aspirin
  2. Clopidogrel
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

List the anticoagulants

A
  1. Heparin
  2. Dalteparin
  3. Enoxaparin
  4. Warfarin
  5. Rivaroxaban
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which of the following is not an anticoagulant?

A. Heparin
B. Warfarin
C. Rivaroxaban
D. Clopidogrel

A

D. Clopidogrel
(anti-thrombotic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which of the following drugs acts by inhibiting fibrinolysis?

A. Vitamin K
B. Protamine sulfate
C. Aminocaproic acid
D. Clopidogrel

A

C. Aminocaproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What drug is used as a specific antidote for anticoagulant rodenticide toxicity?

A

Vitamin K (hemostatic agent)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How can Vitamin K be administered??

A

SQ and oral

anaphylaxis if given IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the DOC for treatment of hemorrhage secondary to heparin overdose?

A. Vitamin K
B. Protamine Sulfate
C. Tranexamic Acid (TXA)
D. Desmopressin

A

B. Protamine Sulfate

  • binds to heparin and inactivates it
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the MOA of Protamine Sulfate?

A
  • binds to heparin and inactivates it
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

List the hemostatic agents

A
  1. Vitamin K
  2. Protamine sulfate
  3. Aminocaproic acid
  4. Tranexamic acid
  5. Desmopressin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

List the thrombolytics

A
  1. Streptokinase
  2. Urokinase
  3. Tissue plasminogen activator
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vitamin K is necessary for synthesis of coagulation factors __________

A

II, VII, IX, X

2, 7, 9, 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When would use of protamine sulfate be contraindicated?

A

If pre-existing thrombosis

(excessive clotting will make it worse)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the DOC for treatment of bleeding due to vonWillebrands disease?

A

Desmopressin

  • Increases plasma factor VIII and plasminogen factor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the MOA of Desmopressin?

A
  • Increases plasma factor VIII and plasminogen factor
  • Supports primary hemostasis and platelet function
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Main clinical indications for use of Desmopressin?

A
  • DOC for tx of bleeding due to vonWillebrands dz
  • DOC for tx of central diabetes insipidus
  • Tx of bleeding due to aspirin toxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

_________ guidelines are available for use of antithrombotics and anticoagulants

A

CURATIVE

18
Q

What is the MOA of low dose aspirin?

A

Antithrombotic

  • Reduces PLT aggregation by irreversibly inhibiting synthesis of Thrombozane A2 (TXA2)
19
Q

When is low dose aspirin used as antithrombotic agent?

A
  1. Tx of thrombotic dz
  2. Feline aortic thromboembolism
  3. IMHA
  4. Hypercoagulable states
20
Q

When is use of low dose aspirin contraindicated?

A

Contraindicated if pre-existing GI ulceration or active GI bleeding

21
Q

What drug would be best to treat feline aortic thromboembolism?

A

Clopidogrel (anti-thrombotic)

22
Q

What are the main clinical indications for use of Clopidogrel?

A
  1. Tx of thrombotic dz
  2. Feline aortic thromboembolism
  3. IMHA
  4. Hypercoagulable states
23
Q

What is the MOA of Clopidogrel?

A
  • Reduces PLT aggregation by selectively inhibiting ADP on the PLT surface
24
Q

When is use of Clopidogrel contraindicated?

A

Contraindicated if pre-existing GI ulceration or active GI bleeding

25
Q

What is the MOA of unfractionated Heparin?

A
  • Anticoagulant
  • Binds to Antithrombin III to inactivate factor XA and prevents conversion of prothrombin to thrombin
26
Q

Which of the following drugs are low molecular weight heparins?

A
  1. Dalteparin
  2. Enoxaparin
27
Q

What is the MOA of Dalteparin?

A
  • Binds to Antithrombin III to inactivate factor XA

(Has minimal effects on thrombin and clotting times unlike unfractionated heparin)

28
Q

What is the MOA of Enoxaparin?

A
  • Binds to Antithrombin III to inactivate factor XA

(Has minimal effects on thrombin and clotting times unlike unfractionated heparin)

29
Q

Which of the following has the most risk of causing prolonged aPTT coagulation time?

A. Unfractionated heparin
B. Enoxaparin
C. Dalteparin
D. Desmopressin

A

A. Unfractionated heparin (anticoagulant)

30
Q

What is the MOA of Warfarin?

A
  • Inhibits Vitamin K epoxide reductase
  • Interferes with Vitamin K synthesis of coagulation factors II, VII, IX, X
31
Q

Warfarin toxicity is reversible with?

A

Vitamin K1 or frozen plasma transfusion

32
Q

What adverse effects can be seen with warfarin use?

A
  • Prolonged clotting times (PT)
  • Life threatening hemorrhage
33
Q

Which 2 drugs have the most risk of causing prolonged PT/PTT clotting times?

A
  • Unfractionated heparin (anticoagulant)
  • Warfarin (anticoagulant)
34
Q

Which of the following drugs is a direct Factor XA inhibitor?

A

Rivaroxaban

35
Q

What is the MOA of Rivaroxaban?

A

Direct factor XA inhibitor

36
Q

What is the MOA of streptokinase?

A

Activates plasminogen to breakdown existing clots (thrombolytic)

37
Q

What is the MOA of urokinase?

A

Activates plasminogen to breakdown existing clots (thrombolytic)

38
Q

What adverse effects can be seen with use of thrombolytics (Streptokinase, Urokinase, Tissue plasminogen activator)?

A

Life threatening hemorrhage

39
Q

What is the MOA of clopidogrel?

A. Anti-PLT aggregation through TXA2 inhibition
B. Anti-PLT aggregation through ADP inhibition
C. Anti-coagulation through factor XA inhibition
D. Antifibrinolysis

A

B. Anti-PLT aggregation through ADP inhibition

40
Q

Which of the following is a fibrin clot-specific thrombolytic?

A. Streptokinase
B. Urokinase
C. Dalteparin
D. Tissue plasminogen activator

A

D. Tissue plasminogen activator

pharm II (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions