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pharm II > Chemotherapy Drugs > Flashcards

Chemotherapy Drugs Flashcards

1
Q

Which 4 drugs are used in a multimodal plan to treat lymphoma?

A
  1. Cyclophosphamide
  2. Doxorubicin
  3. Vincristine
  4. Corticosteroids (Prednisone)
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2
Q

Which of the following chemotherapeutics cross the BBB?

A
  1. Lomustine / CCNU
    (alkylating agent)
  2. Melphalan
    (alkylating agent)
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3
Q

List the alkylating agents used in chemotherapy

A
  1. Cyclophosphamide
  2. Chlorambucil
  3. Lomustine/CCNU
  4. Melphalan
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4
Q

List the anthracycline antibiotics used in chemotherapy

A
  1. Doxorubicin
  2. Mitoxantrone
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5
Q

Which of the following chemotherapeutics binds to tubulin and inhibits microtubule assembly and mitosis?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. Melphalan

A

C. Vinblastine

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6
Q

What are the active metabolites of cyclophosphamide?

A

Phosphoramide mustard > acrolein

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7
Q

Which of the following can cause sterile hemorrhagic cystitis?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. Melphalan

A

A. Cyclophosphamide

Pets must be walked and peed regularly

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8
Q

Clinical uses of Cyclophosphamide?

A
  • Lymphoma in dogs and cats
  • Sarcomas
  • Mammary carcinomas
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9
Q

What are the active metabolite of Chlorambucil?

A

Phenylacetic acid

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10
Q

Clinical uses of Chlorambucil?

A
  • Chronic lymphocytic leukemia (CLL)
  • GI lymphoma
  • TCC of the bladder
  • Alternative to cyclophosphamide if hemorrhagic cystitis
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11
Q

What is the DOC for treatment of multiple myeloma?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. Melphalan

A

D. Melphalan

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12
Q

Clinical uses of CCNU?

A
  • Lymphoma
  • Mast cell tumor
  • Histiocytic sarcoma
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13
Q

Which of the following can cause increased liver enzymes and pulmonary fibrosis in dogs?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. CCNU

A

D. CCNU (Lomustine)

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14
Q

Clinical uses of Doxorubicin?

A
  • Histiocytic sarcoma
  • Adenocarcinoma
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15
Q

Which of the following is a cardiac sparing alternative to doxorubicin?

A

Mitoxantrone

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16
Q

Clinical uses of Mitoxantrone?

A
  • TCC
  • Anal sac adenocarcinoma
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17
Q

Which of the following can result in blue-green urine?
A. Cyclophosphamide
B. Doxorubicin
C. Mitoxantrone
D. Vinblastine

A

C. Mitoxantrone

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18
Q

Main uses of vinblastine?

A
  • Mast cell tumor
  • TCC
  • Rescue for lymphoma
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19
Q

Main uses of vincristine?

A
  • Lymphoma
  • TVT
20
Q

What adverse effects can be seen with Doxorubicin?

A

“red death”
- Cardiotoxic
- Anaphylaxis with rapid IV
- Alopecia and pigmentation
- Vesicant
- Myelosuppression
- GI signs

21
Q

Which of the following would you AVOID in a patient with cardiac issues?

A. Cyclophosphamide
B. Doxorubicin
C. Mitoxantrone
D. Vinblastine

A

B. Doxorubicin

22
Q

Which chemotherapeutic is contraindicated in cats and why?

A

Cisplatin

fatal pulmonary vasculitis and edema

23
Q

Clinical uses for carboplatin?

A
  • Osteosarcoma
  • Adenocarcinoma
24
Q

Clinical uses for cisplatin?

A

Canine only, CONTRAINDICATED in cats
- Osteosarcoma
- TCC

25
Q

Which of the following is a Tyrosine Kinase inhibitor?

A. Cyclophosphamide
B. Masitinib
C. Doxorubicin
D. Mitoxantrone

A

B. Masitinib

(Toceranib too)

26
Q

Main clinical use for RTK inhibitors?

A

(Masitinib and Toceranib)

  • Canine mast cell tumor
27
Q

Which of the following can result in protein loosing nephropathy?

A. Cyclophosphamide
B. Mitoxantrone
C. Doxorubicin
D. Masitinib

A

D. Masitinib

28
Q

Which of the following is not an adverse effect of Tyrosine Kinase inhibitors?

A. Muscle cramping
B. Protein loosing nephropathy
C. Hypotension
D. Hypertension

A

C. Hypotension

(Masitinib and Toceranib can cause HYPERtension)

29
Q

Cyclophosphamide is a ___________

A. Antimicrotubule agent
B. Anthracycline antibiotic
C. Alkylating agent
D. RTK inhibitor

A

C. Alkylating agent

(cell cycle non-specific)

30
Q

Chlorambucil is a ___________

A. Antimicrotubule agent
B. Anthracycline antibiotic
C. Alkylating agent
D. RTK inhibitor

A

C. Alkylating agent

31
Q

Mitoxantrone is a ________

A. Antimicrotubule agent
B. Anthracycline antibiotic
C. Alkylating agent
D. RTK inhibitor

A

B. Anthracycline antibiotic

32
Q

CCNU is a ___________

A. Antimicrotubule agent
B. Anthracycline antibiotic
C. Alkylating agent
D. RTK inhibitor

A

C. Alkylating agent

33
Q

Doxorubicin is a __________

A. Antimicrotubule agent
B. Anthracycline antibiotic
C. Alkylating agent
D. RTK inhibitor

A

B. Anthracycline antibiotic

34
Q

Vinblastine and Vincristine are __________

A. Antimicrotubule agents
B. Anthracycline antibiotics
C. Alkylating agents
D. RTK inhibitors

A

A. Antimicrotubule agents

(cell cycle specific, anti-mitotic)

35
Q

What adverse effects can be seen with use of RTK inhibitors?

A

(Masitinib and Toceranib)
- HYPERtension
- PLN
- Muscle cramping

36
Q

Which of the following chemotherapeutics should be avoided in cats with kidney damage?

A. Cyclophosphamide
B. Mitoxantrone
C. Doxorubicin
D. CCNU

A

C. Doxorubicin

(nephrotoxicity in cats)

37
Q

Liver enzymes should be monitored when using which of the following chemotherapeutics?

A. Cyclophosphamide
B. Mitoxantrone
C. Doxorubicin
D. CCNU

A

D. CCNU

(causes inc. liver enzymes)

38
Q

A. Cyclophosphamide
B. CCNU
C. Doxorubicin
D. Mitoxantrone

A
38
Q

Pulmonary fibrosis is an adverse effect of which chemotherapeutic?

A. Cyclophosphamide
B. CCNU
C. Doxorubicin
D. Mitoxantrone

A

B. CCNU

39
Q

Clinical indications for use of glucocorticoids in cancer therapy?

A
  • Lymphomas
  • Mast cell tumors
  • Insulinoma
  • Brain tumors
  • Paraneoplastic hyperCa
40
Q

Which of the following alkylating agents does NOT require metabolic activation by the liver?

A. Melphalin
B. CCNU
C. Chlorambucil
D. Cyclophosphamide

A

A. Melphalin

41
Q

Which of the following alkylating agents are excreted intact in urine? select all that apply.

A. Melphalin
B. CCNU
C. Chlorambucil
D. Cyclophosphamide

A

A. Melphalin
D. Cyclophosphamide

42
Q

DOC to treat TVT?

A

Vincristine

43
Q

Which of the following causes more myelosuppression?

A. Vincristine
B. Vinblastine

A

B. Vinblastine

BLASTS ur bone marrow

44
Q

Which of the following causes more GI side effects like ileus?

A. Vincristine
B. Vinblastine

A

A. Vincristine

pharm II (23 decks)

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