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Chemotherapy Drugs Flashcards

1
Q

Which 4 drugs are used in a multimodal plan to treat lymphoma?

A
  1. Cyclophosphamide
  2. Doxorubicin
  3. Vincristine
  4. Corticosteroids (Prednisone)
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2
Q

Which of the following chemotherapeutics cross the BBB?

A
  1. Lomustine / CCNU
    (alkylating agent)
  2. Melphalan
    (alkylating agent)
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3
Q

List the alkylating agents used in chemotherapy

A
  1. Cyclophosphamide
  2. Chlorambucil
  3. Lomustine/CCNU
  4. Melphalan
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4
Q

List the anthracycline antibiotics used in chemotherapy

A
  1. Doxorubicin
  2. Mitoxantrone
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5
Q

Which of the following chemotherapeutics binds to tubulin and inhibits microtubule assembly and mitosis?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. Melphalan

A

C. Vinblastine

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6
Q

What are the active metabolites of cyclophosphamide?

A

Phosphoramide mustard > acrolein

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7
Q

Which of the following can cause sterile hemorrhagic cystitis?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. Melphalan

A

A. Cyclophosphamide

Pets must be walked and peed regularly

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8
Q

Clinical uses of Cyclophosphamide?

A
  • Lymphoma in dogs and cats
  • Sarcomas
  • Mammary carcinomas
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9
Q

What are the active metabolite of Chlorambucil?

A

Phenylacetic acid

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10
Q

Clinical uses of Chlorambucil?

A
  • Chronic lymphocytic leukemia (CLL)
  • GI lymphoma
  • TCC of the bladder
  • Alternative to cyclophosphamide if hemorrhagic cystitis
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11
Q

What is the DOC for treatment of multiple myeloma?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. Melphalan

A

D. Melphalan

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12
Q

Clinical uses of CCNU?

A
  • Lymphoma
  • Mast cell tumor
  • Histiocytic sarcoma
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13
Q

Which of the following can cause increased liver enzymes and pulmonary fibrosis in dogs?

A. Cyclophosphamide
B. Doxorubicin
C. Vinblastine
D. CCNU

A

D. CCNU (Lomustine)

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14
Q

Clinical uses of Doxorubicin?

A
  • Histiocytic sarcoma
  • Adenocarcinoma
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15
Q

Which of the following is a cardiac sparing alternative to doxorubicin?

A

Mitoxantrone

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16
Q

Clinical uses of Mitoxantrone?

A
  • TCC
  • Anal sac adenocarcinoma
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17
Q

Which of the following can result in blue-green urine?
A. Cyclophosphamide
B. Doxorubicin
C. Mitoxantrone
D. Vinblastine

A

C. Mitoxantrone

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18
Q

Main uses of vinblastine?

A
  • Mast cell tumor
  • TCC
  • Rescue for lymphoma
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19
Q

Main uses of vincristine?

A
  • Lymphoma
  • TVT
20
Q

What adverse effects can be seen with Doxorubicin?

A

“red death”
- Cardiotoxic
- Anaphylaxis with rapid IV
- Alopecia and pigmentation
- Vesicant
- Myelosuppression
- GI signs

21
Q

Which of the following would you AVOID in a patient with cardiac issues?

A. Cyclophosphamide
B. Doxorubicin
C. Mitoxantrone
D. Vinblastine

A

B. Doxorubicin

22
Q

Which chemotherapeutic is contraindicated in cats and why?

A

Cisplatin

fatal pulmonary vasculitis and edema

23
Q

Clinical uses for carboplatin?

A
  • Osteosarcoma
  • Adenocarcinoma
24
Q

Clinical uses for cisplatin?

A

Canine only, CONTRAINDICATED in cats
- Osteosarcoma
- TCC

25
Which of the following is a Tyrosine Kinase inhibitor? A. Cyclophosphamide B. Masitinib C. Doxorubicin D. Mitoxantrone
B. Masitinib (Toceranib too)
26
Main clinical use for RTK inhibitors?
(Masitinib and Toceranib) - Canine mast cell tumor
27
Which of the following can result in protein loosing nephropathy? A. Cyclophosphamide B. Mitoxantrone C. Doxorubicin D. Masitinib
D. Masitinib
28
Which of the following is not an adverse effect of Tyrosine Kinase inhibitors? A. Muscle cramping B. Protein loosing nephropathy C. Hypotension D. Hypertension
C. Hypotension (Masitinib and Toceranib can cause HYPERtension)
29
Cyclophosphamide is a ___________ A. Antimicrotubule agent B. Anthracycline antibiotic C. Alkylating agent D. RTK inhibitor
C. Alkylating agent (cell cycle non-specific)
30
Chlorambucil is a ___________ A. Antimicrotubule agent B. Anthracycline antibiotic C. Alkylating agent D. RTK inhibitor
C. Alkylating agent
31
Mitoxantrone is a ________ A. Antimicrotubule agent B. Anthracycline antibiotic C. Alkylating agent D. RTK inhibitor
B. Anthracycline antibiotic
32
CCNU is a ___________ A. Antimicrotubule agent B. Anthracycline antibiotic C. Alkylating agent D. RTK inhibitor
C. Alkylating agent
33
Doxorubicin is a __________ A. Antimicrotubule agent B. Anthracycline antibiotic C. Alkylating agent D. RTK inhibitor
B. Anthracycline antibiotic
34
Vinblastine and Vincristine are __________ A. Antimicrotubule agents B. Anthracycline antibiotics C. Alkylating agents D. RTK inhibitors
A. Antimicrotubule agents (cell cycle specific, anti-mitotic)
35
What adverse effects can be seen with use of RTK inhibitors?
(Masitinib and Toceranib) - HYPERtension - PLN - Muscle cramping
36
Which of the following chemotherapeutics should be avoided in cats with kidney damage? A. Cyclophosphamide B. Mitoxantrone C. Doxorubicin D. CCNU
C. Doxorubicin (nephrotoxicity in cats)
37
Liver enzymes should be monitored when using which of the following chemotherapeutics? A. Cyclophosphamide B. Mitoxantrone C. Doxorubicin D. CCNU
D. CCNU (causes inc. liver enzymes)
38
A. Cyclophosphamide B. CCNU C. Doxorubicin D. Mitoxantrone
38
Pulmonary fibrosis is an adverse effect of which chemotherapeutic? A. Cyclophosphamide B. CCNU C. Doxorubicin D. Mitoxantrone
B. CCNU
39
Clinical indications for use of glucocorticoids in cancer therapy?
- Lymphomas - Mast cell tumors - Insulinoma - Brain tumors - Paraneoplastic hyperCa
40
Which of the following alkylating agents does NOT require metabolic activation by the liver? A. Melphalin B. CCNU C. Chlorambucil D. Cyclophosphamide
A. Melphalin
41
Which of the following alkylating agents are excreted intact in urine? select all that apply. A. Melphalin B. CCNU C. Chlorambucil D. Cyclophosphamide
A. Melphalin D. Cyclophosphamide
42
DOC to treat TVT?
Vincristine
43
Which of the following causes more myelosuppression? A. Vincristine B. Vinblastine
B. Vinblastine BLASTS ur bone marrow
44
Which of the following causes more GI side effects like ileus? A. Vincristine B. Vinblastine
A. Vincristine

pharm II (23 decks)

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