renal replacement tx

Question 1

indications for renal replacement tx

Answer 1

Acidosis, Electrolytes, Ingestions, Overload, Uremia

Question 2

what is the concept of clearance

Answer 2

the volume of plasma cleared completely of a given substance per unit time

Question 3

how to create osmotic gradient in peritoneal dialysis soln?

Answer 3

glu in various concentratiosn

Question 4

main complication assc’d with peritoneal dialysis

Answer 4

peritonitis

Question 5

2 most common causes of death in patients on dialysis

Answer 5

1. CV

2. infections

Question 6

what is the preferred method of renal replacement tx

Answer 6

kidney transplantation

Question 7

where do most deceased donor organs come from?

Answer 7

brain dead donors

Question 8

relative contraindication for kidney transplant recipient: estimated life span under

Answer 8

5 yrs

Question 9

induction phase immunosuppr meds (3)

Answer 9

1. corticosteroids
2. anti-thympcyte globulin
3. IL-2 receptor antags

Question 10

what are the calcineurin inhibs (2)

Answer 10

1. cyclosporine

2. tacrolimus

Question 11

immunosuppressive regimen of choice

Answer 11

1. tacrolimus
2. mycophenolate
3. prednisone

Question 12

thrombosis of donor renal artery or vein, occurs in 1st week, dx with U/S with doppler

Answer 12

graft thrombosis

Question 13

elevated Cr, abd pain, Dx with nuclear medicine scan

Answer 13

urine leak

Question 14

what does hyperacute rejection lead to?

Answer 14

immediate graft loss

Question 15

some possibilities to remedy hyperacute rejection

Answer 15

1. plasmapharesis

2. pulse steroid

Question 16

tx for chronic allograft rejection

Answer 16

none

Question 17

leading cause of death in patients receiving transplants

Answer 17

infections

Question 18

what virus lives latently in GU tract and is eactivated by immunsuppre

Answer 18

BV virus

Question 19

most common malignancy assc’d wtih post-transplant patients

Answer 19

skin cancer

Question 20

agent of choice for tx’ing new onset HTN in post transplant patients

Answer 20

CCB (nifedipine, amlodipine, isradapine)