acid base regulation by kidneys Flashcards
typical american diet generates _____mmol H+ per day
50-100
elimination of HCO3 in urine is equivalent to?
adding H to the body
secretion of H by renal tubule cells in proximal tubule uses?
Na-K ATPase & Na-H antiporter
secretion of H by renal tubule cells in distal tubule uses?
ATPase
is the proximal or distal tubule stimulated by low pH to insert an ATPase into the luminal membrane?
distal
carbonic anhydrase converts ____to___and____
carbonic acid to H20 & CO2
net effect of reabsorption of bicarb in proximal tubule
movement of NaHCO2 from filtrate to blood
where is bicarb reabsorbed?
proximal tubule + collecting duct
proximal tubule uses a ____to reabsorb bicarb, vs collecting duct which uses_____
sodium-bicar symporter; bicarb-Cl antiporter
in collecting duct, H+ translocating ATPase is stimulated by?
acid load
limiting urine pH
4.4
what is the most common non-bicarb urinary buffer?
phosphate
for each newly formed H2PO4 excreted in urine, 1 ____is eliminated and one new_____is formed
H+; HCO3
most abundant form of titratable acid
H2PO4-
glutaminase converts____to____
glutamine to glutamate
glutamate is converted to alpha ketoglutarate by_____
glutamate dehydrogenase
in state of alkalosis, what type of cells secrete bicarb into tubular lumen
B type intercalated cells
normal arterial PCO2
40 Torr
normal arterial pH
7.35-7.45
arterial bicarb normal is
24 mmol/L
how is arterial bicarb normally assessed?
- calculated
2. measured
normal urinary titratable acid
0-20 mmol/day
normal ammonium ion
20-40 mEq/day
how is anion gap calculated?
plasma Na - (plasma HCO3 + plasma Cl)
normal anion gap
8-12 mEq/l
a large anion gap would be expected in metabolic alkalosis or acidosid
metabolic acidosis
