disorders of Na & water Flashcards
normal serum sodium
134-145 mmol/L
what are disorders of Na most often caused by
disorders of water
is sx severity related to degree of hyponatremia?
yes, related to rapidity & severity of hyponatremia
what level of serum Na is an absolute indication to tx?
serum Na
in hypoosmolar states, how do brain cells initially adapt?
excrete intracellular osmols–>reduce risk of cellular overhydration
in hyperosmolar states, how do brain cells initially adapt?
produce intracellular osmols–>prevent cellular dehydration
what is osmotic demyelination syndrome
severe demyelination of pons
severe neuro disorder, paraparesis, dysarthia, dysphagia, seizure, coma, death
osmotic demyelination syndrome
hyponatremia with normal water excretion
primary polydipsia
renal failure, CHF, cirrhosis, nephrotic syndrome are examples of ____volemic cause of hyponatremia
hypervolemic
hypoaldrenalism, hypothyroidism, SIAD are ___volemic causes of hyponatremia
euvolemic
inappropriate elevation of ADH despite hyponatremia and euvolemic state
SIAD
how to tx Hyponatremia + volume depletion
0.9 NS
how to tx Severe hyponatremia (
hypertonic (3%) salive
MOA of demeclocycline?
incr urinary water loss
