Na and water homeostasis

Question 1

which type of diuretics acts on proximal tubule

Answer 1

carbonic anhydrase

Question 2

which type of diuretic acts on distal tubule?

Answer 2

thiazides

Question 3

which type of diuretics can results in hypokalemia, hyponatremia

Answer 3

1. loop diuretics

2. thiazides

Question 4

what is sodium concetration determined by?

Answer 4

relative amts of total Na + total body water

Question 5

normal serum osmolality

Answer 5

285-290 mOsm/kg

Question 6

Major determinant of water homeostasis

Answer 6

ADH

Question 7

what part of nephron actively transports NaCl?

Answer 7

thick ascending limb

Question 8

aquaporin 2 is expressed where

Answer 8

apical membrane of collecting tubule cells

Question 9

aquaporin 3, 4 are expresed where?

Answer 9

basolateral membrane of collecting tubule cells

Question 10

SIADH is defined when ECF _____ mOsm/kg with inappropriate urinary concentration ______ mOsm/kg

Answer 10

ECF under 270; urinary concentration >100

Question 11

what is effective mechanism for preventing further hypernatremia when renal concentration is impaired

Answer 11

thirst