RCC Flashcards
1
Q
Origin
A
From proximal tubule cells -> polygonal clear cells
2
Q
Filled with
A
lipid and carb
3
Q
Most common
A
men 50-70 years of age,
increased incidence with smoking and obesity
4
Q
Clinical manifestation
A
hematuria, palpable mass, 2nd polycythemia, flank pain, fever, and weight loss.
5
Q
Invasion
A
Invades renal vein then IVC and spreads hematogenously;
metastasizes to lung and bone
6
Q
Prevalence
A
Most common renal malignancy
7
Q
Genetic mutation
A
VHL on chromosome 3
8
Q
Paraneoplastic syndrome
A
1) ectopic EPO
2) ACTH
3) PTHrP
9
Q
When does it present?
A
Silent cancer because in retroperitoneum,
commonly presents as a metastatic neoplasm
10
Q
Treatment:
A
resection if localized
resistant to conventional chemo and radiation.
