ACE inhibitors

Question 1

Names

Answer 1

Captopril, enalapril, lisinopril

Question 2

MOA

Answer 2

inhibit ACE, thus decrease angiotensin II
This decreases GFR by preventing constriction of efferent arterioles.

Levels of renin increase as a result of loss of feedback inhibition.

Inhibition of ACE also prevents inactivation of bradykinin, a potent vasodilator

Question 3

Clinical use

Answer 3

HTN, CHF, proteinuria, diabetic renal disease

Prevent unfavorable heart remodeling as a result of chronic HTN.

Question 4

Toxicity

Answer 4

CATCHH

Cough
Angioedema
Teratogen (fetal renal malformations)
Creatinine increase (low GFR)
Hyperkalemia
Hypotension

Avoid in bilateral renal artery stenosis, bc ACE inhibitor will further lower GFR -> renal failure.