Diuretics: loop diuretics Flashcards
1
Q
Loop diuretics
A
Furosemide and ethacrynic acid
2
Q
Furosemide:
A
sulfonamide loop diuretic
inhibit cotransport system (Na, K, 2Cl) of thick ascending.
Abolishes hypertonicity of medulla, preventing concentration of urine.
Stimulates PGE release (vasodilatory effect on afferent)
Increases Ca2+ excretion
“Loop loses Ca2+”
3
Q
Furosemide use
A
Edematous states (CHF, cirrhosis, nephrotic, pulm edema)
HTN
Hypercalcemia
4
Q
Furosemide toxicity
A
OH DANG!
Ototoxicity Hypokalemia Dehydration Allergy (sulfa) Nephritis (interstitial) Gout
5
Q
Ethacrynic acid
A
Phenoxyacetic acid derivative (not sulfonamide)
Essentially same action as furosemide
6
Q
Ethacrynic acid use
A
Diuresis in pts with sulfa allergy
7
Q
Ethacrynic acid toxicity
A
Similar to furosemide
Can cause hyperuricemia,
NEVER use to treat gout
