Changes in glomerular dynamics

Question 1

Prostagladins

Answer 1

Dilates afferent arterioles, thus

Increase RPF,
Increase GFR
so FF (GFR/RPF) remains constant

Question 2

NSAIDS

Answer 2

Blocks prostagladin, so constricts afferent arterioles,

Decrease RPF,
Decreased GFR
So FF (GFR/RPF) remains constant

Question 3

Angiotensin II

Answer 3

Constricts efferent arterioles, thus

Decreases RPF,
Increases GFR,
So FF (GFR/RPF) increases

Question 4

ACE inhibitors

Answer 4

Dilates efferent arterioles, thus

Increases RPF
Decreases GFR
So FF (GFR/RPF) decreases

Question 5

Afferent arteriole constriction

Answer 5

RPF: decrease
GFR: decrease

FF (GFR/RPF) : not changed

Question 6

Efferent arteriole constriction

Answer 6

RPF: decrease
GFR: increase

FF (GFR/RPF) : increase

Question 7

Increase in [plasma protein]

Answer 7

RPF: not changed
GFR: decrease

FF (GFR/RPF) : decreased

Question 8

Decrease in [plasma protein]

Answer 8

RPF: not changed
GFR: increase

FF (GFR/RPF) : increased

Question 9

Constriction of ureter

Answer 9

RPF: not changed
GFR: decrease

FF (GFR/RPF) : decreased

Question 10

Calculation of reabsorption and secretion rate:

Filtered load

Answer 10

GFR x plasma concentraiton

Question 11

Calculation of reabsorption and secretion rate:

Excretion rate

Answer 11

V* Urine concentration

Question 12

Calculation of reabsorption and secretion rate:

Reabsorption

Answer 12

Reabsorption = filtered - excreted

Question 13

Calculation of reabsorption and secretion rate:

Secretion

Answer 13

Secretion = excreted - filtered.