Kidney endocrine function

Question 1

EPO

Answer 1

Released by interstitial cell in the peritubular capillary bed in response to hypoxia

Question 2

1,25- (OH)2 vitamin D

Answer 2

Proximal tubule cells convert 25-OH vitamin D to
1,25-(OH)2 vitamin D(active form)

via 1alpha hydroxylase, which is activated PTH

Question 3

Renin

Answer 3

Secreted by JG cells in response to decreased renal arterial pressure and increased renal sympathetic tone

Question 4

Prostagladin

Answer 4

Paracrine secretion

Vasodilates the afferent arteriole to increase GFR

Question 5

NSAID effect?

Answer 5

Blocks renal production of prostagladins,
thus no longer keeping afferent arterioles dilated,
leading to acute renal failure.