Diuretics: mannitol and acetazolamide

Question 1

Mannitol

Answer 1

Osmotic, increases urine flow

decreased intracranial/intraocular pressure

Question 2

Mannitol use

Answer 2

Use: drug overdose, to lower IC/IO pressure

Question 3

Manitol toxicity

Answer 3

Toxicity: pulm edema, dehydration, contraindicated in anuria, CHF

Question 4

Acetazolamide

Answer 4

Carbonic anhydrase inhibitor

Causes self limited NaHCO3 diuresis and reduction in total body HCO3- stores

Question 5

Acetazolamide use

Answer 5

Glaucoma
urinary alkalinization
metabolic alkalosis,
altitude sickness (resp alkalosis)
pseudotumor cerebri

(makes urine basic, body acidic)

Question 6

Acetazolamide toxicity

Answer 6

Hyperchloremic metabolic acidosis;
paresthesias,
NH3 toxicity,
sulfa allergy

“ACIDazolamide causes ACIDosis”