RCC Flashcards
1
Q
Age at diagnosis for which germline testing is indicated for RCC
A
Younger than 46
2
Q
RCC IHC
A
PAX2+
PAX8+
CK7 and CK20 negative
3
Q
Is there nodal dissection with nephrectomy?
A
No
4
Q
Indications for adjuvant pembro in RCC
A
- T2 with nuclear grade 4 or sarcomatoid differentiation
- T3a or higher
- node positive
- M1 NED
5
Q
Mutation seen in chromophobe
A
Folliculin (FLCN)
6
Q
Stage IV RCC
A
metastatic disease OR invasion beyond Gerota’s fascia
7
Q
Systemic therapy typically preferred for non clear cell
A
cabo
8
Q
First line for STage IV papillary RCC
A
cabo/nivo
9
Q
Frontline for metastatic renal medullary carcinoma
A
combination platinum-based cytotoxic chemotherapy,
10
Q
What drugs have shown a DFS benefit in the adjuvant setting for RCC
A
- pembro
*Also sunitinib!
