Pharmacology Flashcards
Obinutuzumab mechanism
Type II humanized anti-CD20 MABs
Black box warnings for CD20 MAbs
- Hep B reactivation
- PML
- Infusion reactions (Rituxan)
- Severe mucocutaenous reaction (Rituxan)
Dara SE’s
- infusion reactions
- myelosuppression
- ## herpes reactivation
Tafasitamab mechaism
Humanized CD19 mAb that mediates B-cell lysis through apoptosis and immune effector mechanisms
Tafastimab SE’s
- bone marrow suppression
- peripheral edema
mogamulizumab mechanism
Humanized CCR4 mAb that results in target cell depletion through antibody-dependent cellular cytotoxicity
mogamulizumab indication
mycosis fungoides/sezary syndrome
mogamulizumab SE’s
- increased transplant in complications, including mortality, if administered less than 50 days before HSCT
- autoimmune toxicity (myositis, myocarditis, hepatitis, pneumonitis)
Brentuximab vedotin mechanism
CD30 ADC w/ MMAE as payload
polatuzumab vedotin mechanism
- CD79B ADC w/ MMAE as payload
Inotuzumab target
CD22
Inotuzumab black box warnings
1) hepatotoxicity/VOD
2) higher day 100 post-HSCT mortality rate
loncastuximab mechanism
Humanized CD19 ADC designed to deliver tesirine to malignant cells
Drugs that are active against BCR-ABL T3151 mutation
ponatinib
*asciminib
What do IMIDS target?
CRBN protein (induces proteasome degradation)
Difference in mechanism between bortezomib and carfilzomib
- bortezomin is reversible proteasome inhibition, carfilzomib is irreversible inhibition
Major benefit of giving bortezomib subcutaneously
Less peripheral neuropathy than IV bortezomib
What are the HDAC (histone deacytelase) inhibitors?
- vorinostat
- belinostat
- romidepsin
HDAC inhibitor SE’s
- QTc prolongation
- infection
pirtobrutinib unique mechanism as BTK inhibitor
non-covalent
*binds to wild type BTK as well as BTK harboring C481 mutations
Gilteritinib SE’s
- differentiation syndrome
- prolonged QT interval
Midostaurin SE’s
- increased creatinine
- mucositis
- prolonged QT intrval
- MSK pain and arthralgias
Primary SE to know for IDH inhibitors
- differentiation syndrome
Primary SE to know for selinexor
Hyponatremia
