Cholangiocarcinoma Flashcards
1
Q
cholangio RF’s
A
- gallstones
- porcelain gallbladder
- gallbladder polyps
- *liver fluke infection
- hep b and c
- lynch, PSC
2
Q
Biopsy vs. surgery if patient has tumor on gallbladder intraoperatively
A
- surgeon removes directly
3
Q
Point of portal vein embolization pre-operatively for hepatectomy
A
induces hypertrophy of remaining segments of liver prior to surgical resection of HCC or cholangio
4
Q
Lymph nodes that need to be resection for adequate lymphadenectomy for intrahepatic cholangio
A
6
5
Q
Actionable mutations in cholangio
A
FGFR fusions
IDH1
*BRAF
HER2
6
Q
Approved targeted therapies for FGFR fusions in cholangio
A
pemigatinib
*futibatinib
7
Q
FGFR targeted therapy side effects
A
hyperphosphatemia
ocular toxicities
hyperbilirubinemia
8
Q
Management of resectable extrahepatic and intrahepatic cholangiocarcinoma
A
upfront surgery
adjuvant capecitabine as per BILCAP
9
Q
second line for cholangio
A
FOLFOX
