Infusion reactions Flashcards
1
Q
Type 2 hypersensitivity mechanism
A
Antibody mediated (IgG and IgM), activating complement
*No prior exposure required
2
Q
Type 3 hypersensitivity mechanism
A
- immune complex
3
Q
Type 4 hypersensitivity mechanism
A
- cell mediated hypersensitivity
*contact dermatitis
4
Q
Symptoms suggestive of anaphylaxis
A
urticaria + repetitive cough + wheeze + dyspnea throat tightness/change in voice + hypotension
5
Q
Drug classes with highest rate of infusion reactions
A
- taxanes
- platinums
- monoclonal abs
6
Q
Platinum hypersensitivity mechanism
A
Type 1 IgE mediated
7
Q
Type 1 hypersensitivity mechanism
A
IgE mediated
8
Q
Taxol reaction mechanism
A
chremophor (now called cholofor, which is used for drug solubility)
9
Q
docetaxel reaction mechanism
A
polysorbate (also used for drug solubility)
10
Q
Timeline for risk of hypersensitivity with monoclonal antibodies
A
Typically becomes less common with repeated doses
11
Q
A
