Melanoma

Question 1

First line management of acral melanoma

Answer 1

Checkpoint inhibitors

Question 2

Drug approved for uveal melanoma and 2) HLA

Answer 2

HLA-A*02:01-positive
Tebentafusp

Question 3

Size threshold for SNLB in melanoma

Answer 3

Greater than 0.8 mm

Question 4

Dabrafenib tremetinib SE to know

Answer 4

Pyrexia

Question 5

encobimetinib SE to know

Answer 5

ocular toxicity

Question 6

Gene mutation associated with hereditary melanoma

Answer 6

CDKN2A
p16

Question 7

FAM syndrome presentation

Answer 7

A lot of atypical appearing moles

Question 8

Other genetic syndromes associated with melanoma

Answer 8

BRCA2
pTEN (Cowden)
BAP1

Question 9

Stage III melanoma definition

Answer 9

nodal mets OR *in transit metastases

Question 10

Other indications for sentinel lymph node biopsy

Answer 10

• regression of tumor below breslow depth
• if base of tumor broadly transected on specimen (indicating tumor much thicker than actual read on path)
• presence of atypical features (melanocytic tumor of unknown potential)

Question 11

TVEC mechanism + role

Answer 11

• oncolytic virus
• very limited role, possibly local control in elderly patient ineligible for immunotherapy